Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division.
Sculpting an Embryo: The Interplay between Mechanical Force and Cell Division.
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DOI：
10.3390/jdb10030037
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发表时间：
2022-09-01
影响因子：
2.7
通讯作者：
Woolner S
中科院分区：
文献类型：
--
作者：
Tarannum N;Singh R;Woolner S
在最基本的层面上，从单个受精细胞到多细胞生物的旅程是由有丝分裂细胞分裂精心安排的。细胞分裂的速率和方向对于确保胚胎的正常发育都很重要。在细胞增殖的同时，胚胎细胞不断经历来自周围组织环境的各种机械力。细胞必须能够正确读取这些力并做出反应，因为已知它们会影响多种生物功能，包括细胞分裂。机械环境和细胞分裂之间的相互作用在胚胎发生过程中尤其重要，此时组织的形状、结构和整体组织会发生动态变化，以产生功能性组织和器官。在这里，我们回顾了目前对机械力调节细胞分裂的细胞机制的理解，并将这些知识置于胚胎发生和组织形态发生的背景下。
The journey from a single fertilised cell to a multicellular organism is, at the most fundamental level, orchestrated by mitotic cell divisions. Both the rate and the orientation of cell divisions are important in ensuring the proper development of an embryo. Simultaneous with cell proliferation, embryonic cells constantly experience a wide range of mechanical forces from their surrounding tissue environment. Cells must be able to read and respond correctly to these forces since they are known to affect a multitude of biological functions, including cell divisions. The interplay between the mechanical environment and cell divisions is particularly crucial during embryogenesis when tissues undergo dynamic changes in their shape, architecture, and overall organisation to generate functional tissues and organs. Here we review our current understanding of the cellular mechanisms by which mechanical force regulates cell division and place this knowledge within the context of embryogenesis and tissue morphogenesis.
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DOI：
10.1073/pnas.1701703114
发表时间：
2017-07-18
影响因子：
11.1
作者：
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通讯作者：
Gloerich, Martijn
影响因子：
4.6
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影响因子：
7.7
作者：
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影响因子：
11.4
作者：
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通讯作者：
Bergstralh, Dan T.
影响因子：
64.8
作者：
Gudipaty SA;Lindblom J;Loftus PD;Redd MJ;Edes K;Davey CF;Krishnegowda V;Rosenblatt J
通讯作者：
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