Evolutionary Precedents for Behavioral Actions of Oxytocin and Vasopressin a
Evolutionary Precedents for Behavioral Actions of Oxytocin and Vasopressin a
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催产素和加压素 a 行为作用的进化先例
DOI：
10.1111/j.1749-6632.1992.tb34352.x
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发表时间：
1992
影响因子：
5.2
通讯作者：
F. L. Moore
中科院分区：
文献类型：
--
作者：
F. L. Moore
很明显，哺乳动物的催产素和抗利尿激素的行为行为不是新获得的，而是有进化的先例。对鱼类、两栖动物、爬行动物和鸟类的注射研究表明，AVT可以激活某些生殖行为。AVT在控制生殖行为方面起核心作用的最有力证据来自对细粒绦虫的研究。在这种两栖动物中，注射AVT激动剂会激活雄性的求偶行为（振幅紧握）和雌性的产卵行为，而注射AVT拮抗剂会抑制这些行为。此外，在Taricha雄性中，AVT在特定大脑区域的浓度与求爱行为的表达有关。基于对这种两栖动物的研究，可以得出关于类固醇-肽相互作用的几个结论。首先，性腺类固醇激素维持雄性和雌性AVT的行为行为。在Taricha，性腺切除和类固醇植入恢复avt诱导的雄性求偶和雌性产卵。其次，性腺类固醇通过调节目标神经元上的AVT受体数量来维持AVT的行为作用。在Taricha男性和女性中，性腺切除术降低了某些大脑区域（杏仁核外侧部）的AVT受体浓度（但没有结合亲和力），而不是其他区域。第三，性腺类固醇的类型决定了AVT是诱导雄性还是雌性的生殖行为。去卵巢的Taricha雌性对AVT注射的反应是雌二醇注射后的产卵行为和双氢睾酮注射后的雄性样痉挛。第四，雌性avt诱导行为的雄性化很可能反映了雄激素对avt合成神经元的位点特异性作用。在Taricha，视顶盖的AVTir浓度是两性二态的（雄性高于雌性），在繁殖季节雄性达到峰值。第五，特定脑区的AVT含量随着行为的执行而增加。在Taricha中，表现出求偶行为的雄性的DPOA、CSF和腹侧漏斗中的AVTir浓度高于没有求偶行为的雄性。这些结论说明了控制行为的类固醇-肽相互作用如何涉及多个神经解剖位点和神经化学作用。
It is clear that the behavioral actions of oxytocin and vasopressin in mammals are not newly acquired, but have evolutionary antecedents. Injection studies with fish, amphibians, reptiles, and birds indicate that AVT can activate certain reproductive behaviors. The strongest evidence that AVT acts centrally to control reproductive behaviors comes from research on T. granulosa. In this amphibian, injections of AVT agonists activate courtship behaviors (amplectic clasping) in males and egg-laying behaviors in females, whereas injections of AVT antagonists inhibit the behaviors. Also, in Taricha males, AVT concentrations in specific brain areas are associated with the expression of courtship behaviors. Several conclusions about steroid-peptide interactions can be drawn, based on research with this amphibian. First, gonadal steroid hormones act to maintain the behavioral actions of AVT in both males and females. In Taricha, gonadectomy abolishes and steroid implants restore AVT-induced courtship in males and egg-laying in females. Second, gonadal steroids maintain the behavioral actions of AVT, in part, by modulating AVT receptor numbers on target neurons. In Taricha males and females, gonadectomy reduces AVT receptor concentrations (but not binding affinity) in certain brain areas (amygdala pars lateralis) and not others. Third, the type of gonadal steroid determines whether AVT elicits male-like or female-like reproductive behaviors. Ovariectomized Taricha females respond to AVT injections with egg-laying behaviors when implanted with estradiol and with male-like amplectic clasping when implanted with dihydrotestosterone. Fourth, the masculinization of AVT-induced behaviors in females most likely reflects site-specific actions of androgens on AVT-synthesizing neurons. In Taricha, AVTir concentrations in the optic tectum are sexually dimorphic (higher in males than females) and reach peak levels in males during the breeding season. Fifth, AVT content in specific brain areas increase as a function of performing the behaviors. In Taricha, AVTir concentrations in DPOA, CSF, and ventral infundibulum are higher in males that exhibit courtship behaviors than in males that do not. These conclusions illustrate how steroid-peptide interactions in the control of behaviors entail multiple neuroanatomical sites and neurochemical actions.
雄性粗皮蝾螈（塔里查颗粒）显微解剖大脑区域中黄体生成素释放激素浓度的季节性变化。
影响因子：
2.7
作者：
Zoeller,RT;Moore,FL
通讯作者：
Moore,FL
两栖动物大脑下丘脑和下丘脑外区域的精氨酸催产素免疫反应性。
影响因子：
4.1
作者：
Zoeller,RT;Moore,FL
通讯作者：
Moore,FL
影响因子：
56.9
作者：
KELLEY, DB
通讯作者：
KELLEY, DB