PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3(+) T cells.
PEDV infection in neonatal piglets through the nasal cavity is mediated by subepithelial CD3(+) T cells.
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新生仔猪经鼻腔感染 PEDV 是由上皮下 CD3( ) T 细胞介导的
DOI：
10.1186/s13567-020-00883-w
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发表时间：
2021-02-17
影响因子：
4.4
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Yuan C;Jin Y;Li Y;Zhang E;Zhang P;Yang Q
猪流行性腹泻病毒(PEDV)主要感染新生仔猪，对全球养猪业造成灾难性影响。PEDV通过鼻腔感染仔猪，在这一过程中树突状细胞(DC)发挥着重要作用。然而，新生仔猪的鼻树突状细胞较少。本研究发现上皮下CD3+T细胞介导PEDV经鼻腔侵袭新生仔猪。PEDV可在新生仔猪鼻腔分离的鼻上皮细胞(NECS)中复制。PEDV感染NECS可在晚期诱导抗病毒和炎性细胞因子。感染的NECS通过细胞间接触将病毒传递给分布于鼻腔上皮下的CD3+T细胞。感染的CD3+T细胞可通过血液循环迁移到肠道，引起新生仔猪肠道感染。因此，本研究结果提示CD3+T细胞在新生仔猪PEDV从鼻腔传播到肠道粘膜中的重要作用。
Porcine epidemic diarrhea virus (PEDV) primarily infects neonatal piglets causing catastrophic effects on the global pig farming industry. PEDV infects piglets through the nasal cavity, a process in which dendritic cells (DCs) play an important role. However, neonatal piglets have fewer nasal DCs. This study found that subepithelial CD3+ T cells mediated PEDV invasion through the nasal cavity in neonatal piglets. PEDV could replicate in the nasal epithelial cells (NECs) isolated from the nasal cavity of neonatal piglets. Infection of NECs with PEDV could induce antiviral and inflammatory cytokines at the late stage. The infected NECs mediated transfer of virus to CD3+ T cells distributed in the subepithelial of the nasal cavity via cell-to-cell contact. The infected CD3+ T cells could migrate to the intestine via blood circulation, causing intestinal infection in neonatal piglets. Thus, the findings of this study indicate the importance of CD3+T cells in the dissemination of PEDV from the nasal cavity to the intestinal mucosa in neonatal piglets.
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