An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure.
An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure.
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DOI：
10.1289/ehp.1307049
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发表时间：
2014-04
影响因子：
10.4
通讯作者：
Cohen A
中科院分区：
文献类型：
--
作者：
Burnett RT;Pope CA 3rd;Ezzati M;Olives C;Lim SS;Mehta S;Shin HH;Singh G;Hubbell B;Brauer M;Anderson HR;Smith KR;Balmes JR;Bruce NG;Kan H;Laden F;Prüss-Ustün A;Turner MC;Gapstur SM;Diver WR;Cohen A
背景：估算因长期暴露于环境空气中的细颗粒物（PM2.5）所致疾病负担需要了解相对风险（RR）函数的形状和幅度。然而，缺乏足够的直接证据来确定在世界许多地方所观察到的高环境浓度下的死亡率RR函数的形状。
目的：我们针对成年人的死亡原因制定了涵盖全球整个暴露范围的RR函数：缺血性心脏病（IHD）、脑血管疾病（中风）、慢性阻塞性肺疾病（COPD）和肺癌（LC）。我们还制定了急性下呼吸道感染（ALRI）发病率的RR函数，可用于估算5岁以下儿童的死亡率和健康生命损失年数。
方法：我们通过整合来自环境空气污染（AAP）、二手烟草烟雾、家庭固体烹饪燃料和主动吸烟（AS）研究的可用RR信息，拟合了一个综合暴露 - 反应（IER）模型。使用吸入的颗粒质量剂量将主动吸烟暴露转换为估计的年度PM2.5暴露当量。我们根据全球估计的环境PM2.5浓度，计算出每个国家的人群归因分数（PAF）。
结果：与之前在负担评估中使用的其他七种形式相比，IER模型是RR的更优预测因子。因AAP暴露所致的PAF百分比在各国之间有所不同，IHD为2% - 41%，中风为1% - 43%，COPD为<1% - 21%，LC为<1% - 25%，ALRI为<1% - 38%。
结论：我们通过整合来自产生颗粒物排放的不同燃烧类型的RR信息，开发了一个基于细颗粒物质量的RR模型，该模型涵盖了全球暴露范围。随着新的RR信息的出现，该模型可以更新。
引用：伯内特RT，波普CA三世，埃扎蒂M，奥利夫斯C，林SS，梅塔S，申HH，辛格G，哈贝尔B，布劳尔M，安德森HR，史密斯KR，巴尔梅斯JR，布鲁斯NG，阚H，拉登F，普鲁斯 - 乌斯滕A，特纳MC，加斯图尔SM，迪弗WR，科恩A。2014年。用于估算因环境细颗粒物暴露所致全球疾病负担的综合风险函数。《环境健康展望》122:397 - 403；http://dx.doi.org/10.1289/ehp.1307049
Background: Estimating the burden of disease attributable to long-term exposure to fine particulate matter (PM2.5) in ambient air requires knowledge of both the shape and magnitude of the relative risk (RR) function. However, adequate direct evidence to identify the shape of the mortality RR functions at the high ambient concentrations observed in many places in the world is lacking. Objective: We developed RR functions over the entire global exposure range for causes of mortality in adults: ischemic heart disease (IHD), cerebrovascular disease (stroke), chronic obstructive pulmonary disease (COPD), and lung cancer (LC). We also developed RR functions for the incidence of acute lower respiratory infection (ALRI) that can be used to estimate mortality and lost-years of healthy life in children < 5 years of age. Methods: We fit an integrated exposure–response (IER) model by integrating available RR information from studies of ambient air pollution (AAP), second hand tobacco smoke, household solid cooking fuel, and active smoking (AS). AS exposures were converted to estimated annual PM2.5 exposure equivalents using inhaled doses of particle mass. We derived population attributable fractions (PAFs) for every country based on estimated worldwide ambient PM2.5 concentrations. Results: The IER model was a superior predictor of RR compared with seven other forms previously used in burden assessments. The percent PAF attributable to AAP exposure varied among countries from 2 to 41 for IHD, 1 to 43 for stroke, < 1 to 21 for COPD, < 1 to 25 for LC, and < 1 to 38 for ALRI. Conclusions: We developed a fine particulate mass–based RR model that covered the global range of exposure by integrating RR information from different combustion types that generate emissions of particulate matter. The model can be updated as new RR information becomes available. Citation: Burnett RT, Pope CA III, Ezzati M, Olives C, Lim SS, Mehta S, Shin HH, Singh G, Hubbell B, Brauer M, Anderson HR, Smith KR, Balmes JR, Bruce NG, Kan H, Laden F, Prüss-Ustün A, Turner MC, Gapstur SM, Diver WR, Cohen A. 2014. An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect 122:397–403; http://dx.doi.org/10.1289/ehp.1307049
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影响因子：
11.4
作者：
Brauer, Michael;Amann, Markus;Burnett, Rick T.;Cohen, Aaron;Dentener, Frank;Ezzati, Majid;Henderson, Sarah B.;Krzyzanowski, Michal;Martin, Randall V.;Van Dingenen, Rita;van Donkelaar, Aaron;Thurston, George D.
通讯作者：
Thurston, George D.
影响因子：
168.9
作者：
Pirie, Kirstin;Peto, Richard;Beral, Valerie
通讯作者：
Beral, Valerie
影响因子：
--
作者：
Northcross, Amanda;Chowdhury, Zohir;Smith, Kirk R.
通讯作者：
Smith, Kirk R.
影响因子：
168.9
作者：
Lim, Stephen S.;Vos, Theo;Flaxman, Abraham D.;Danaei, Goodarz;Shibuya, Kenji;Adair-Rohani, Heather;Amann, Markus;Anderson, H. Ross;Andrews, Kathryn G.;Aryee, Martin;Atkinson, Charles;Bacchus, Loraine J.;Bahalim, Adil N.;Balakrishnan, Kalpana;Balmes, John;Barker-Collo, Suzanne;Baxter, Amanda;Bell, Michelle L.;Blore, Jed D.;Blyth, Fiona;Bonner, Carissa;Borges, Guilherme;Bourne, Rupert;Boussinesq, Michel;Brauer, Michael;Brooks, Peter;Bruce, Nigel G.;Brunekreef, Bert;Bryan-Hancock, Claire;Bucello, Chiara;Buchbinder, Rachelle;Bull, Fiona;Burnett, Richard T.;Byers, Tim E.;Calabria, Bianca;Carapetis, Jonathan;Carnahan, Emily;Chafe, Zoe;Charlson, Fiona;Chen, Honglei;Chen, Jian Shen;Cheng, Andrew Tai-Ann;Child, Jennifer Christine;Cohen, Aaron;Colson, K. Ellicott;Cowie, Benjamin C.;Darby, Sarah;Darling, Susan;Davis, Adrian;Degenhardt, Louisa;Dentener, Frank;Des Jarlais, Don C.;Devries, Karen;Dherani, Mukesh;Ding, Eric L.;Dorsey, E. Ray;Driscoll, Tim;Edmond, Karen;Ali, Suad Eltahir;Engell, Rebecca E.;Erwin, Patricia J.;Fahimi, Saman;Falder, Gail;Farzadfar, Farshad;Ferrari, Alize;Finucane, Mariel M.;Flaxman, Seth;Fowkes, Francis Gerry R.;Freedman, Greg;Freeman, Michael K.;Gakidou, Emmanuela;Ghosh, Santu;Giovannucci, Edward;Gmel, Gerhard;Graham, Kathryn;Grainger, Rebecca;Grant, Bridget;Gunnell, David;Gutierrez, Hialy R.;Hall, Wayne;Hoek, Hans W.;Hogan, Anthony;Hosgood, H. Dean, III;Hoy, Damian;Hu, Howard;Hubbell, Bryan J.;Hutchings, Sally J.;Ibeanusi, Sydney E.;Jacklyn, Gemma L.;Jasrasaria, Rashmi;Jonas, Jost B.;Kan, Haidong;Kanis, John A.;Kassebaum, Nicholas;Kawakami, Norito;Khang, Young-Ho;Khatibzadeh, Shahab;Khoo, Jon-Paul;Kok, Cindy;Laden, Francine;Lalloo, Ratilal;Lan, Qing;Lathlean, Tim;Leasher, Janet L.;Leigh, James;Li, Yang;Lin, John Kent;Lipshultz, Steven E.;London, Stephanie;Lozano, Rafael;Lu, Yuan;Mak, Joelle;Malekzadeh, Reza;Mallinger, Leslie;Marcenes, Wagner;March, Lyn;Marks, Robin;Martin, Randall;McGale, Paul;McGrath, John;Mehta, Sumi;Mensah, George A.;Merriman, Tony R.;Micha, Renata;Michaud, Catherine;Mishra, Vinod;Hanafiah, Khayriyyah Mohd;Mokdad, Ali A.;Morawska, Lidia;Mozaffarian, Dariush;Murphy, Tasha;Naghavi, Mohsen;Neal, Bruce;Nelson, Paul K.;Miquel Nolla, Joan;Norman, Rosana;Olives, Casey;Omer, Saad B.;Orchard, Jessica;Osborne, Richard;Ostro, Bart;Page, Andrew;Pandey, Kiran D.;Parry, Charles D. H.;Passmore, Erin;Patra, Jayadeep;Pearce, Neil;Pelizzari, Pamela M.;Petzold, Max;Phillips, Michael R.;Pope, Dan;Pope, C. Arden, III;Powles, John;Rao, Mayuree;Razavi, Homie;Rehfuess, Eva A.;Rehm, Juergen T.;Ritz, Beate;Rivara, Frederick P.;Roberts, Thomas;Robinson, Carolyn;Rodriguez-Portales, Jose A.;Romieu, Isabelle;Room, Robin;Rosenfeld, Lisa C.;Roy, Ananya;Rushton, Lesley;Salomon, Joshua A.;Sampson, Uchechukwu;Sanchez-Riera, Lidia;Sanman, Ella;Sapkota, Amir;Seedat, Soraya;Shi, Peilin;Shield, Kevin;Shivakoti, Rupak;Singh, Gitanjali M.;Sleet, David A.;Smith, Emma;Smith, Kirk R.;Stapelberg, Nicolas J. C.;Steenland, Kyle;Stoeckl, Heidi;Stovner, Lars Jacob;Straif, Kurt;Straney, Lahn;Thurston, George D.;Tran, Jimmy H.;Van Dingenen, Rita;van Donkelaar, Aaron;Veerman, J. Lennert;Vijayakumar, Lakshmi;Weintraub, Robert;Weissman, Myrna M.;White, Richard A.;Whiteford, Harvey;Wiersma, Steven T.;Wilkinson, James D.;Williams, Hywel C.;Williams, Warwick;Wilson, Nicholas;Woolf, Anthony D.;Yip, Paul;Zielinski, Jan M.;Lopez, Alan D.;Murray, Christopher J. L.;Ezzati, Majid
通讯作者：
Ezzati, Majid
影响因子：
10.4
作者：
Anenberg SC;Horowitz LW;Tong DQ;West JJ
通讯作者：
West JJ