The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism.
The composite autonomic symptom scale 31 is a useful screening tool for patients with Parkinsonism.
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DOI：
10.1371/journal.pone.0180744
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Youn J
中科院分区：
文献类型：
--
作者：
Kim Y;Seok JM;Park J;Kim KH;Min JH;Cho JW;Park S;Kim HJ;Kim BJ;Youn J
以帕金森综合征为主的多系统萎缩(MSA-P)和帕金森病(PD)的鉴别很重要，但尚未确定有效的鉴别工具。我们研究了综合自主神经症状量表31(COMPASS 31)问卷作为评估帕金森病患者自主神经功能的有效性。在这项研究中，我们招募了患有MSA-P和PD的药物未成熟的患者，并进行了COMPASS-31和客观自主神经功能障碍测试(AFT)。比较两组的人口统计学和临床数据，包括帕金森症和自主神经功能障碍。此外，我们还确定了区分MSA-P和PD的最佳COMPASS 31分界值作为筛查工具。本研究纳入27例MSA-P患者和41例PD患者。COMPASS 31总分与客观AFT结果有较好的相关性。当我们比较两组之间的COMPASS 31分时，MSA-P患者在立位不耐受、胃肠道和膀胱域的总分和分项得分高于PD患者。同样，在客观AFT中，MSA-P患者较PD患者在呼气/吸气比、Valsalva比率和压力恢复时间方面的异常更多。以13.25作为诊断MSA-P的临界值，COMPASS-31总分具有高度的敏感性(92.6%)和中等的特异性(51.2%)，曲线下面积为0.765。根据我们的结果，COMPASS 31是评估帕金森病患者自主神经功能的有效工具。COMPASS-31可作为一种灵敏、方便的筛查工具，尤其可用于区分MSA-P和PD。
Differentiation of multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD) is important, but an effective tool for differentiation has not been identified. We investigated the efficacy of the composite autonomic symptom scale 31 (COMPASS 31) questionnaire as a tool for evaluating autonomic function in parkinsonism patients. In this study, we enrolled drug-naïve patients with MSA-P and PD, and administered the COMPASS-31 and an objective autonomic dysfunction test (AFT). Demographic and clinical data, including parkinsonism and autonomic dysfunction, were compared between the two groups. Additionally, we determined the optimal COMPASS 31 cut-off score to differentiate MSA-P from PD for use as a screening tool. In this study, 27 MSA-P patients and 41 PD patients were recruited. The total COMPASS 31 score was well correlated with the objective AFT results. When we compared the COMPASS 31 score between the two groups, MSA-P patients showed higher total scores and sub-scores in the orthostatic intolerance, gastrointestinal, and bladder domains compared with PD patients. Similarly, MSA-P patients had more abnormalities in expiration to inspiration ratio, Valsalva ratio and pressure recovery time than PD patients in objective AFT. With 13.25 as the cut-off score for diagnosis of MSA-P, the total COMPASS-31 score demonstrated high sensitivity (92.6%) and moderate specificity (51.2%) with an area under the curve of 0.765. Based on our results, the COMPASS 31 is an effective tool for evaluation of autonomic function in patients with parkinsonism. The COMPASS-31 could be used as a sensitive and convenient screening tool, especially for the differentiation between MSA-P and PD.
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影响因子：
5.1
作者：
Treister R;O'Neil K;Downs HM;Oaklander AL
通讯作者：
Oaklander AL
影响因子：
1.2
作者：
Novak, Peter
通讯作者：
Novak, Peter
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
轻度和晚期帕金森病的心血管自主神经功能障碍。
影响因子：
3.9
作者：
Kim JS;Lee SH;Oh YS;Park JW;An JY;Park SK;Han SR;Lee KS
通讯作者：
Lee KS
影响因子：
8.6
作者：
Chung, Eun Joo;Lee, Won Yon;Lee, Gyeong Han
通讯作者：
Lee, Gyeong Han