Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially.
Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially.
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DOI：
10.1016/j.jand.2012.09.022
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发表时间：
2013-02
影响因子：
4.8
通讯作者：
Picklo, Matthew J., Sr.
中科院分区：
文献类型：
--
作者：
Raatz, Susan K.;Rosenberger, Thad A.;Johnson, LuAnn K.;Wolters, William W.;Burr, Gary S.;Picklo, Matthew J., Sr.
增加omega-3脂肪酸(n-3)的摄入量有助于降低心血管疾病(CVD)的风险。在人口层面上增加消费可能更好地通过饮食来解决，而不是通过补充。然而，关于鱼摄入量的剂量反应对血浆n-3脂肪酸水平的影响的数据有限。为了比较不同剂量的养殖大西洋三文鱼对健康受试者血浆磷脂脂肪酸(PLFA)比例和心血管风险生物标记物(葡萄糖、胰岛素、HOMAIR、hsCRP和IL-6)的影响，我们进行了一项随机3期交叉设计试验(4周治疗，4-8周清洗)，以比较19名明显健康的男性和女性两次/周食用90、180和270克养殖大西洋三文鱼的影响，这些男性和女性的平均年龄为40-65岁，BMI在25-34.9公斤/平方米之间。所有的研究访问都是在美国农业部，ARS大叉人类营养研究中心进行的。各剂量组的EPA和总n-3均呈剂量效应增加(p<；0.05)，180和270g剂量组的总n-3分别为8.03±0.26和9.21±0.26%。亚油酸对治疗的反应没有改变，而花生四烯酸(P<；0.0001)和总omega-6脂肪酸(n-6)呈剂量依赖性地减少(<；0.0001)。在饲料中添加180g和270g的养殖大西洋鲑鱼，每周两次，持续4wk，改变了n-3和n-6的PLFA比例，从而降低了患心血管疾病的风险。
Enhanced omega-3 fatty acid (n-3) intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish intake on plasma levels of n-3 fatty acids. To compare the effects of different doses of farmed Atlantic salmon on plasma phospholipid fatty acid (PLFA) proportions and CVD risk biomarkers (glucose, insulin, HOMAIR, hsCRP, and IL-6) in healthy subjects we performed a randomized 3-period cross-over designed trial (4 wk treatment, 4-8 wk washout) to compare the effects of twice/wk consumption of farmed Atlantic salmon at doses of 90, 180, and 270 g in 19 apparently healthy men and women with a mean age of aged 40-65 years and a BMI between 25-34.9 kg/m2. All study visits were conducted at the USDA, ARS Grand Forks Human Nutrition Research Center. EPA and total n-3 were increased (p<0.05) by all treatments in a dose response manner, with total n-3 of 8.03 ± 0.26 and 9.21 ± 0.26 % for 180 and 270 g doses, respectively. Linoleic acid did not change in response to treatment while arachidonic acid (P<0.05) and total omega-6 fatty acids (n-6) decreased dose dependently (<0.0001). The addition of farmed Atlantic salmon to the diet twice/wk for 4 wk at portions of 180g and 270g modifies PLFA proportions of n-3 and n-6 in a level associated with decreased risk for CVD.
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影响因子：
6.1
作者：
Raatz SK;Golovko MY;Brose SA;Rosenberger TA;Burr GS;Wolters WR;Picklo MJ Sr
通讯作者：
Picklo MJ Sr
影响因子：
5.3
作者：
Calzada, Catherine;Colas, Romain;Lagarde, Michel
通讯作者：
Lagarde, Michel
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
39.2
作者：
Mozaffarian, Dariush;Lemaitre, Rozenn N.;Siscovick, David S.
通讯作者：
Siscovick, David S.
影响因子：
7.1
作者：
Blasbalg, Tanya L.;Hibbeln, Joseph R.;Rawlings, Robert R.
通讯作者：
Rawlings, Robert R.