The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).
The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).
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DOI：
10.1016/j.jacc.2018.08.2149
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发表时间：
2018-10-30
影响因子：
24
通讯作者：
Kovacic JC
中科院分区：
文献类型：
--
作者：
Lavine KJ;Pinto AR;Epelman S;Kopecky BJ;Clemente-Casares X;Godwin J;Rosenthal N;Kovacic JC
巨噬细胞是心脏组织的组成部分，对健康和患病的心脏产生深远的影响。采用先进分子技术的范式转换研究揭示了这些巨噬细胞群体中存在的显着复杂性。在这最后的4部分审查系列涵盖巨噬细胞在心血管疾病中，我们审查的起源，动力学，细胞表面标志物，和各自的功能，每一个心脏巨噬细胞亚群确定的日期，包括在心肌炎和心肌梗死后的具体情况。展望未来，更深入地了解心脏巨噬细胞的多样性和通常的二分法功能对于开发靶向治疗以减轻损伤和协调患病心脏的恢复至关重要。此外，由于巨噬细胞对心脏愈合至关重要，因此它们是旨在最小化心肌细胞死亡、改善病理性心脏重塑以及治疗心力衰竭和心肌梗死后的治疗策略的新兴焦点。巨噬细胞是心脏组织的组成部分，对健康和患病的心脏具有深远的影响。范式转换研究揭示了心脏中巨噬细胞群体的显着复杂性。在这4部分回顾系列的最后一部分，我们回顾了起源，动力学，细胞表面标志物，以及迄今为止确定的每个心脏巨噬细胞亚群的各自功能，包括在心肌炎和心肌梗死后。更深入地了解心脏巨噬细胞的多样性和通常的二分法功能对于开发靶向治疗以减轻损伤和协调患病心脏的恢复至关重要。
Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies employing advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, we review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in the specific scenarios of myocarditis and after myocardial infarction. Looking ahead, a deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart. Moreover, as macrophages are critical for cardiac healing, they are an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death, ameliorating pathological cardiac remodeling, and for treating heart failure and after myocardial infarction. Macrophages are integral components of cardiac tissue with profound effects on the healthy and diseased heart. Paradigm shifting studies have revealed significant complexity within macrophage populations that reside in the heart. In this final part of a 4-part review series we review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in myocarditis and after myocardial infarction. A deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart.
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DOI：
10.1084/jem.20120690
发表时间：
2013-11-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Avraham-Davidi I;Yona S;Grunewald M;Landsman L;Cochain C;Silvestre JS;Mizrahi H;Faroja M;Strauss-Ayali D;Mack M;Jung S;Keshet E
通讯作者：
Keshet E
影响因子：
20.1
作者：
DeBerge M;Yeap XY;Dehn S;Zhang S;Grigoryeva L;Misener S;Procissi D;Zhou X;Lee DC;Muller WA;Luo X;Rothlin C;Tabas I;Thorp EB
通讯作者：
Thorp EB
影响因子：
24
作者：
Courties, Gabriel;Heidt, Timo;Sebas, Matthew;Iwamoto, Yoshiko;Jeon, Derrick;Truelove, Jessica;Tricot, Benoit;Wojtkiewicz, Greg;Dutta, Partha;Sager, Hendrik B.;Borodovsky, Anna;Novobrantseva, Tatiana;Klebanov, Boris;Fitzgerald, Kevin;Anderson, Daniel G.;Libby, Peter;Swirski, Filip K.;Weissleder, Ralph;Nahrendorf, Matthias
通讯作者：
Nahrendorf, Matthias
影响因子：
5.5
作者：
Cook, DN
通讯作者：
Cook, DN
影响因子：
4.8
作者：
Dehn，Shirley;Thorp，Edward B.
通讯作者：
Thorp，Edward B.