Macrophages clean up: efferocytosis and microbial control.
Macrophages clean up: efferocytosis and microbial control.
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巨噬细胞清理：胞吞作用和微生物控制。
DOI：
10.1016/j.mib.2013.10.007
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发表时间：
2014-02
影响因子：
5.4
通讯作者：
Behar, Samuel M.
中科院分区：
文献类型：
--
作者：
Martin, Constance J.;Peters, Kristen N.;Behar, Samuel M.
Phagocytic leukocytes, predominantly macrophages, not only ingest and destroy invading pathogens, but are charged with clearing dead and dying host cells. The process of engulfing apoptotic cells is called efferocytosis and has long been appreciated for its role in the resolution of inflammation. New evidence is emerging that efferocytosis represents a double-edged sword in microbial immunity. While efferocytosis of influenza and Mycobacterium tuberculosis-infected cells results in pathogen destruction, efferocytosis of Leishmania-infected neutrophils may promote infection. Understanding how macrophages, dendritic cells (DC) and neutrophils process pathogens encased within a dying cell could lead to the development of novel therapeutics that simultaneously suppress inflammation and promote pathogen clearance.
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