Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity
Gingival Crevicular Fluid: Biomarkers of Periodontal Tissue Activity
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龈沟液：牙周组织活性的生物标志物
DOI：
10.1177/08959374940080022901
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发表时间：
1994
影响因子：
--
通讯作者：
R. Waddington
中科院分区：
文献类型：
--
作者：
G. Embery;R. Waddington
由于缺乏精确的临床标准来评估牙周病，人们开始寻找确定活动性疾病部位、未来破裂部位的预后以及对治疗的反应的替代方法。这篇综述强调了龈沟液中存在的生物标志物的潜在阵列，这些生物标志物可能与正在发生代谢变化的现有或预测的组织区域有关，并来自细菌或宿主细胞衍生的产物。在前者中可以列出内毒素、胺、丁酸盐和各种酶及其抑制剂，例如胰蛋白酶样蛋白酶和细菌胶原酶。由宿主细胞产生的是多种白细胞水解酶、乳铁蛋白和溶菌酶。这些似乎是有用的炎症标志物，并且可以与结缔组织分解的产物区分开，结缔组织分解的产物包括胶原和非胶原产物，包括胶原肽、骨连接蛋白和纤连蛋白。蛋白聚糖作为可能的骨吸收活性的生物标志物特别受欢迎。免疫反应也受到关注，包括免疫球蛋白、补体、类花生酸和细胞因子。这篇综述列出了龈沟液中存在这些物质的可用信息，并尽可能将其存在与疾病活动联系起来。
The lack of precise clinical criteria for assessment of periodontal disease has led to a search for alternative means of determining active disease sites, prognosis of future sites of breakdown, and response to therapy. This review highlights the potential array of biomarkers present in gingival crevicular fluid and which may relate to existing or predicted tissue regions undergoing metabolic change and derived from bacterial or host-cell-derived products. Among the former may be listed endotoxin, amines, butyrate, and a variety of enzymes and their inhibitors, such as trypsin-like proteases and bacterial collagenase. Arising from host cells is a variety of leucocytic hydrolase enzymes, lactoferrin, and lysozyme. These appear to be useful inflammatory markers and may be distinguished from products of connective tissue breakdown which include collagenous and non-collagenous products, including collagen peptides, osteonectin, and fibronectin. The proteoglycans have found particular favor as biomarkers of possible bone-resorptive activity. Attention has also been directed at the immune response, including comment on immunoglobulins, complement, eicosanoids, and cytokines. This review lists available information on the presence of these in gingival sulcus fluid and wherever possible relates their presence to disease activity.
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慢性炎症对人体结缔组织中胶原蛋白类型组成的影响。
DOI：
10.1016/s0174-173x(83)80014-4
发表时间：
1983
期刊：
Collagen and related research
影响因子：
--
作者：
Narayanan,AS;Engel,LD;Page,RC
通讯作者：
Page,RC
沟液中的酶活性用于检测和预测慢性成人牙周炎患者的临床附着丧失。
影响因子：
4.3
作者：
Lamster,IB;Oshrain,RL;Harper,DS;Celenti,RS;Hovliaras,CA;Gordon,JM
通讯作者：
Gordon,JM
活动牙周部位与稳定牙周部位龈沟液中的 IgG 亚类。
影响因子：
4.3
作者：
Reinhardt,RA;McDonald,TL;Bolton,RW;DuBois,LM;Kaldahl,WB
通讯作者：
Kaldahl,WB
龈沟液中的羟脯氨酸滴度。
影响因子：
3.5
作者：
Svanberg,GK
通讯作者：
Svanberg,GK
影响因子：
4.3
作者：
FRIEDMAN, SA;MANDEL, ID;HERRERA, MS
通讯作者：
HERRERA, MS