Limited BDNF contributes to the failure of injury to skin afferents to produce a neuropathic pain condition
Limited BDNF contributes to the failure of injury to skin afferents to produce a neuropathic pain condition
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有限的 BDNF 导致皮肤传入神经损伤无法产生神经性疼痛
DOI：
10.1016/j.pain.2009.10.032
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发表时间：
2010-01
期刊：
影响因子：
7.4
通讯作者：
Zhong, Yi
中科院分区：
文献类型：
--
作者：
Yang, Tao;Wei, Xu-Hong;Liu, Xian-Guo;Liu, Cui-Cui;Li, Yong-Yong;Zhou, Li-Hua;Zhou, Li-Jun;Xin, Wen-Jun;Ren, Wen-Jie;Zhong, Yi
虽然大量证据表明周围神经损伤通常会引起神经性疼痛，但也有临床研究表明，几乎只支配皮肤的腓肠神经的损伤不会引起神经性疼痛。然而，其基本机制在很大程度上是未知的。在目前的工作中，我们发现，无论是腓肠肌比目鱼肌（GS）神经支配骨骼肌或胫神经供应肌肉和皮肤，但不是腓肠神经的横断产生持久的机械异常性疼痛和热痛觉过敏的成年大鼠。高频刺激（HFS）或损伤胫神经或腓肠神经均可引起脊髓背角C纤维诱发电位的晚相长时程增强（L-LTP），而高频刺激或损伤腓肠神经仅引起早相LTP（E-LTP）。此外，胫神经的HFS诱导由腓肠神经刺激诱发的C-纤维反应的L-LTP，并且通过脊髓应用TrkB-Fc（BDNF清除剂）完全防止异位L-LTP。脊髓应用低剂量BDNF（10 pg/ml）使HFS的腓肠神经产生同源L-LTP。最后，我们发现，GS神经损伤，而不是腓肠神经损伤上调BDNF在DRG神经元，BDNF的上调不仅发生在受损的神经元，而且在许多未受伤的。因此，腓肠神经损伤后不产生神经病理性疼痛可能是由于生理和病理条件下神经含有不足的BDNF。
Although a large body of evidence has shown that peripheral nerve injury usually induces neuropathic pain, there are also clinical studies demonstrating that injury of the sural nerve, which almost only innervates skin, fails to do so. The underlying mechanism, however, is largely unknown. In the present work, we found that the transection of either the gastrocnemius–soleus (GS) nerve innervating skeletal muscle or tibial nerve supplying both muscle and skin, but not of the sural nerve produced a lasting mechanical allodynia and thermal hyperalgesia in adult rats. High-frequency stimulation (HFS) or injury of either the tibial nerve or the GS nerve induced late-phase long-term potentiation (L-LTP) of C-fiber-evoked field potentials in spinal dorsal horn, while HFS or injury of the sural nerve only induced early-phase LTP (E-LTP). Furthermore, HFS of the tibial nerve induced L-LTP of C-fiber responses evoked by the stimulation of the sural nerve and the heterotopic L-LTP was completely prevented by spinal application of TrkB-Fc (a BDNF scavenger). Spinal application of low dose BDNF (10 pg/ml) enabled HFS of the sural nerve to produce homotopic L-LTP. Finally, we found that injury of the GS nerve but not that of the sural nerve up-regulated BDNF in DRG neurons, and that the up-regulation of BDNF occurred not only in injured neurons but also in many uninjured ones. Therefore, the sural nerve injury failing to produce neuropathic pain may be due to the nerve containing insufficient BDNF under both physiological and pathological conditions.
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DOI：
--
发表时间：
2004-10
期刊：
Sheng li xue bao : [Acta physiologica Sinica]
影响因子：
--
作者：
Hong-Mei Zhang;Li-Jun Zhou;Xiao-Dong Hu;Neng-Wei Hu;Tong Zhang;Xian-Guo Liu
通讯作者：
Hong-Mei Zhang;Li-Jun Zhou;Xiao-Dong Hu;Neng-Wei Hu;Tong Zhang;Xian-Guo Liu
影响因子：
3.4
作者：
Gu, HY;Chai, H;Wu, WT
通讯作者：
Wu, WT
影响因子：
2.5
作者：
SWETT, JE;WOOLF, CJ
通讯作者：
WOOLF, CJ
DOI：
10.1097/med.0b013e328014979e
发表时间：
2007-04-01
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Boulton, Andrew J M
通讯作者：
Boulton, Andrew J M
影响因子：
4.2
作者：
Wen-jun Xin;Qing-Juan Gong;Ji-Tian Xu;Hong-Wei Yang;Y. Zang;Tong Zhang;Yongyong Li;Xian-Guo Liu
通讯作者：
Wen-jun Xin;Qing-Juan Gong;Ji-Tian Xu;Hong-Wei Yang;Y. Zang;Tong Zhang;Yongyong Li;Xian-Guo Liu