Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats.
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats.
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DOI：
10.1371/journal.pone.0075906
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Masuyama T
中科院分区：
文献类型：
--
作者：
Naito Y;Sawada H;Oboshi M;Fujii A;Hirotani S;Iwasaku T;Okuhara Y;Eguchi A;Morisawa D;Ohyanagi M;Tsujino T;Masuyama T
虽然铁被报道与慢性肾脏疾病的发病机制有关，但铁是否参与肾硬化的病理生理尚不清楚。在此，我们研究铁是否参与了高血压肾病的发展，以及铁限制对盐负荷的易卒中的自发性高血压大鼠（SHRSP）肾硬化的影响。SHRSP给予正常或高盐饮食8周。另一个亚组的SHRSP被喂食高盐和铁限制的饮食。给予高盐饮食的SHRSP发展为严重的高血压和肾硬化。结果，8周饮食后存活率下降。重要的是，在盐负荷的SHRSP的肾脏中观察到大量的铁积累和铁含量增加，沿着超氧化物产生增加、尿8-羟基-2 ′-脱氧鸟苷排泄增加和尿铁排泄增加;然而，这些变化被铁限制显著减弱。感兴趣的是，细胞铁转运蛋白，转铁蛋白受体1和二价金属转运蛋白1的表达增加，在盐负载SHRSP的小管。值得注意的是，铁限制减弱严重高血压和肾硬化的发展，从而提高盐负荷SHRSP的存活率。总之，这些结果表明，铁在高血压肾病的发展中发挥作用的一种新的机制，并建立铁限制盐诱导的肾硬化的影响。
Although iron is reported to be associated with the pathogenesis of chronic kidney disease, it is unknown whether iron participates in the pathophysiology of nephrosclerosis. Here, we investigate whether iron is involved in the development of hypertensive nephropathy and the effects of iron restriction on nephrosclerosis in salt- loaded stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP were given either a normal or high-salt diet for 8 weeks. Another subset of SHRSP were fed a high-salt with iron-restricted diet. SHRSP given a high-salt diet developed severe hypertension and nephrosclerosis. As a result, survival rate was decreased after 8 weeks diet. Importantly, massive iron accumulation and increased iron content were observed in the kidneys of salt-loaded SHRSP, along with increased superoxide production, urinary 8-Hydroxy-2′-deoxyguanosine excretion, and urinary iron excretion; however, these changes were markedly attenuated by iron restriction. Of interest, expression of cellular iron transport proteins, transferrin receptor 1 and divalent metal transporter 1, was increased in the tubules of salt-loaded SHRSP. Notably, iron restriction attenuated the development of severe hypertension and nephrosclerosis, thereby improving survival rate in salt-loaded SHRSP. Taken together, these results suggest a novel mechanism by which iron plays a role in the development of hypertensive nephropathy and establish the effects of iron restriction on salt-induced nephrosclerosis.
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DOI：
10.1152/ajpheart.00463.2008
发表时间：
2009-03-01
影响因子：
4.8
作者：
Naito, Yoshiro;Tsujino, Takeshi;Masuyama, Tohru
通讯作者：
Masuyama, Tohru
影响因子：
168.9
作者：
Antonios, TFT;MacGregor, GA
通讯作者：
MacGregor, GA
影响因子：
8.3
作者：
Naito, Yoshiro;Hirotani, Shinichi;Masuyama, Tohru
通讯作者：
Masuyama, Tohru
影响因子：
13.6
作者：
Izuhara, Y;Nangaku, M;Miyata, T
通讯作者：
Miyata, T
影响因子：
13.2
作者：
NANKIVELL, BJ;BOADLE, RA;HARRIS, DCH
通讯作者：
HARRIS, DCH