Anti-inflammatory therapy in chronic disease: challenges and opportunities.
Anti-inflammatory therapy in chronic disease: challenges and opportunities.
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DOI：
10.1126/science.1230720
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发表时间：
2013-01-11
期刊：
影响因子：
--
通讯作者：
Glass CK
中科院分区：
文献类型：
--
作者：
Tabas I;Glass CK
许多广泛和破坏性的慢性疾病，包括动脉粥样硬化，2型糖尿病和阿尔茨海默病，具有病理生理学上重要的炎症成分。在这些疾病中，炎症刺激的确切身份通常是未知的，即使已知，也难以去除。因此，人们对治疗性靶向炎症反应感兴趣。尽管在由原发性炎症失调或自身免疫引发的慢性疾病中抗炎治疗已经取得了成功，但存在相当大的局限性。特别是，炎症反应对生存至关重要。因此，冗余、补偿途径和必要性缩小了抗炎药物的风险：受益比。然而，在理解炎症信号传导及其与解决途径的联系方面的新进展，以及新药开发，为转化生物医学研究的这一领域提供了希望。
A number of widespread and devastating chronic diseases, including atherosclerosis, type 2 diabetes, and Alzheimer’s disease, have a pathophysiologically important inflammatory component. In these diseases, the precise identity of the inflammatory stimulus is often unknown and, if known, is difficult to remove. Thus, there is interest in therapeutically targeting the inflammatory response. Although there has been success with anti-inflammatory therapy in chronic diseases triggered by primary inflammation dysregulation or autoimmunity, there are considerable limitations. In particular, the inflammatory response is critical for survival. As a result, redundancy, compensatory pathways, and necessity narrow the risk:benefit ratio of anti-inflammatory drugs. However, new advances in understanding inflammatory signaling and its links to resolution pathways, together with new drug development, offer promise in this area of translational biomedical research.
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