Analysis of cytokine profiles in sera of single and multiple infantile hemangioma
Analysis of cytokine profiles in sera of single and multiple infantile hemangioma
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单发性和多发性婴儿血管瘤血清细胞因子谱分析
DOI：
10.1111/1346-8138.16781
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jinnin Masatoshi
中科院分区：
文献类型：
--
作者：
Sakata Mariko;Kunimoto Kayo;Kawaguchi Ami;Inaba Yutaka;Kaminaka Chikako;Yamamoto Yuki;Kakimoto Nobuyuki;Suenaga Tomohiro;Tokuhara Daisuke;Jinnin Masatoshi
婴儿血管瘤（IH）是婴儿期常见的良性血管肿瘤。它们的生长、大小、位置和深度各不相同，尽管大多数病变相对较小，但大约五分之一的患者有多个病变。 IH的危险因素包括女性、低出生体重、多胎妊娠、早产、黄体酮治疗和家族史，但引起多发病变的机制尚不清楚。我们假设血液细胞因子是多种 IH 的病因，并尝试使用单次和多发 IH 患者的血清和膜阵列来证明这一点。血清样本取自五名多发性病变患者和四名单发性病变患者，这些患者均未接受过任何治疗。使用人血管生成抗体膜阵列测量 20 种细胞因子的血清水平。 20种细胞因子中的4种（bFGF、IFN-γ、IGF-I和TGF-β1）在多发病变患者中高于单发病变患者，差异有统计学意义（p<0.05）。值得注意的是，IFN-γ 信号在所有多次 IH 病例中都很明显，但在单次 IH 病例中不存在。尽管不显着，但 IFN-γ 和 IGF-I 之间（r= 0.64，p= 0.065）以及 IGF-I 和 TGF-β1 之间（r= 0.63，p= 0.066）之间存在轻度相关性。 bFGF 水平与病变数量密切相关 (r= 0.88，p= 0.0020)。总之，血液细胞因子可能是多种 IH 的原因。这是一项小规模的试点研究，因此有必要进行进一步的大规模研究。
Infantile hemangiomas (IH) are benign vascular tumors that are common in infancy. They vary in growth, size, location, and depth, and although most lesions are relatively small, approximately one fifth of patients have multiple lesions. Risk factors for IH include female sex, low birth weight, multiple gestation, preterm birth, progesterone therapy, and family history, but the mechanism that causes multiple lesions is unclear. We hypothesized that blood cytokines are involved as a cause of multiple IHs, and tried to prove this using sera and membrane arrays from patients with single and multiple IHs. Serum samples were obtained from five patients with multiple lesions and four patients with a single lesion, none of which had received any treatment. Serum levels of 20 cytokines were measured using human angiogenesis antibody membrane array. Four of the 20 cytokines (bFGF, IFN‐γ, IGF‐I, and TGF‐β1) were higher in the patients with multiple lesions than in those with single lesion, with statistically significant difference (p< 0.05). Notably, signal for IFN‐γ was evident in all cases with multiple IHs, but was absent in cases with single IH. Although not significant, there was mild correlation between IFN‐γ and IGF‐I (r= 0.64,p= 0.065), and between IGF‐I and TGF‐β1 (r= 0.63,p= 0.066). bFGF levels were strongly and significantly correlated with the number of lesions (r= 0.88,p= 0.0020). In conclusion, blood cytokines could act as a cause of multiple IHs. This is a pilot study with a small cohort, so further large‐scale studies are necessary.
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影响因子：
2.4
作者：
Peng, Qiang;Liu, Wenying;Ji, Yi
通讯作者：
Ji, Yi
影响因子：
3.6
作者：
Park, Meerim;Jung, Hye Lim;Choi, Young Bae
通讯作者：
Choi, Young Bae
MMPs-2/9 的组织和血清 mRNA 谱可作为婴儿血管瘤和癌症疾病中最个体化方法的潜在新型生物标志物。
影响因子：
2.8
作者：
K. Taran;Aneta Wnęk;J. Kobos;E. Andrzejewska;P. Przewratil
通讯作者：
P. Przewratil
DOI：
--
发表时间：
2010
期刊：
J Dermatol. 37巻
影响因子：
--
作者：
Jinnin M;Ishihara T;Boye E;et al.
通讯作者：
et al.
影响因子：
2.1
作者：
Babiak-Choroszczak, Lidia;Gizewska-Kacprzak, Kaja;Baglaj, Maciej
通讯作者：
Baglaj, Maciej