Development of novel cascade type crystallizer for continuous production of crystalline particles
Development of novel cascade type crystallizer for continuous production of crystalline particles
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开发用于连续生产晶粒的新型级联式结晶器
DOI：
10.1016/j.jiec.2020.06.021
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发表时间：
2020
影响因子：
6.1
通讯作者：
Takiyama Hiroshi
中科院分区：
文献类型：
--
作者：
Koyama Mana;Kudo Shoji;Amari Shuntaro;Takiyama Hiroshi
连续结晶工艺的引入引起了医药产品的广泛关注。我们设计了一种新型的连续结晶器，它包括Couette-Taylor设备和MSMPR设备以级联方式集成。此外，为MSMPR和Couette-Taylor设备提供进料溶液，以灵活控制MSMPR设备的过饱和，而不考虑Couette-Taylor设备的过饱和。本文研究了新型级联式结晶器的操作参数与结晶质量之间的关系。我们发现所获得的结晶颗粒的质量取决于提供给库埃特-泰勒设备的进料溶液的流量比。此外，该结晶器还提高了结晶产物的收率。因此，我们期望提出由Couette-Taylor和MSMPR设备组成的新型级联式结晶器，以获得不同质量的结晶产品。
The introduction of a continuous crystallization process has been attracting attention for the pharmaceutical products. We designed a novel continuous crystallizer, which includes Couette–Taylor equipment integrated with MSMPR equipment in a cascading manner. Additionally, feed solutions were supplied to MSMPR and Couette–Taylor equipment to flexibly control the supersaturation of the MSMPR equipment, regardless of the supersaturation of Couette–Taylor equipment. In this study, the relationship between operating parameters in novel cascade–type crystallizer and final crystal quality was investigated. We found that the quality of the obtained crystalline particles depend on the flow-rate ratio of the feed solution supplied to Couette–Taylor equipment. Furthermore, the yield of crystalline products was improved using proposed crystallizer. Therefore, we expect proposed novel cascade–type crystallizer consisting of Couette–Taylor and MSMPR equipment to obtain crystalline products with various quality.
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影响因子：
3.8
作者：
Luehrmann, Marie-Christine;Timmermann, Jan;Wohlgemuth, Kerstin
通讯作者：
Wohlgemuth, Kerstin
影响因子：
4.7
作者：
M. Oullion;F. Puel;G. Févotte;S. Righini;P. Carvin
通讯作者：
M. Oullion;F. Puel;G. Févotte;S. Righini;P. Carvin
连续MSMPR结晶器启动操作的晶种规格设计
影响因子：
5.2
作者：
H. Takiyama;M. Matsuoka
通讯作者：
M. Matsuoka
集成连续纯化加工制药生产操作的流程优化
影响因子：
4.7
作者：
Maitraye Sen;A. Rogers;Ravendra Singh;A. Chaudhury;Joyce John;M. Ierapetritou;R. Ramachandran
通讯作者：
R. Ramachandran
基于群体平衡模型的多段多次添加 (MSMA) 连续推流式反溶剂结晶器的多目标优化
DOI：
--
发表时间：
2014
期刊：
影响因子：
--
作者：
Bradley J. Ridder;Aniruddha Majumder;Z. Nagy
通讯作者：
Z. Nagy