The therapeutic importance of acid-base balance.
The therapeutic importance of acid-base balance.
复制标题
酸碱平衡的治疗重要性。
DOI：
10.1016/j.bcp.2020.114278
复制
发表时间：
2021-01
影响因子：
5.8
通讯作者：
Occhipinti R
中科院分区：
文献类型：
--
作者：
Quade BN;Parker MD;Occhipinti R
小苏打和醋几代人以来一直被用作家庭疗法，今天我们只需点击鼠标，就可以声称小苏打，柠檬汁和苹果醋是从癌症到COVID-19的奇迹疗法。尽管有这些似是而非的说法，控制酸碱平衡的治疗价值是无可争议的，并且是食品和药物管理局批准的便秘，癫痫，代谢性酸中毒和消化性溃疡治疗的基础。在这篇叙述性综述中，我们提供了证据支持对抗局部和全身酸碱失衡的当前和潜在治疗价值，其中一些确实涉及小苏打（碳酸氢钠）的管理。此外，我们还讨论了药物对酸碱平衡的副作用以及酸碱状态对药物药代动力学性质的影响。我们的综述考虑了所有主要的器官系统以及与几个临床专业相关的信息，如麻醉学、传染病学、肿瘤学、牙科学和外科学。
Baking soda and vinegar have been used as home remedies for generations and today we are only a mouse-click away from claims that baking soda, lemon juice, and apple cider vinegar are miracles cures for everything from cancer to COVID-19. Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. In this narrative review, we present evidence in support of the current and potential therapeutic value of countering local and systemic acid-base imbalances, several of which do in fact involve the administration of baking soda (sodium bicarbonate). Furthermore, we discuss the side effects of pharmaceuticals on acid-base balance as well as the influence of acid-base status on the pharmacokinetic properties of drugs. Our review considers all major organ systems as well as information relevant to several clinical specialties such as anesthesiology, infectious disease, oncology, dentistry, and surgery.
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影响因子：
8
作者：
Abou Alaiwa, Mahmoud H.;Launspach, Janice L.;Zabner, Joseph
通讯作者：
Zabner, Joseph
影响因子：
2.5
作者：
Ahn, Shin;Kim, Youn-Jung;Kim, Won Young
通讯作者：
Kim, Won Young
影响因子：
2.5
作者：
Ahsan MK;Tchernychev B;Kessler MM;Solinga RM;Arthur D;Linde CI;Silos-Santiago I;Hannig G;Ameen NA
通讯作者：
Ameen NA
影响因子：
--
作者：
Baliga S;Muglikar S;Kale R
通讯作者：
Kale R
DOI：
10.2215/cjn.03600413
发表时间：
2013-12-06
影响因子：
9.8
作者：
Amodu, Afolarin;Abramowitz, Matthew K.
通讯作者：
Abramowitz, Matthew K.