Association between AKT1 gene polymorphisms and depressive symptoms in the Chinese Han population with major depressive disorder.
Association between AKT1 gene polymorphisms and depressive symptoms in the Chinese Han population with major depressive disorder.
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中国汉族重度抑郁症人群AKT1基因多态性与抑郁症状的相关性
DOI：
10.3969/j.issn.1673-5374.2012.03.014
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发表时间：
2012-01-25
影响因子：
6.1
通讯作者：
Zhang K
中科院分区：
文献类型：
--
作者：
Yang C;Sun N;Ren Y;Sun Y;Xu Y;Li A;Wu K;Zhang K
本研究招募了 461 名中国汉族抑郁症患者。通过PCR扩增和直接测序确定AKT1基因型和等位基因分布。使用 UNPHASED 软件分析 17 项汉密尔顿抑郁量表、总分、四个因素与 AKT1 rs2494746 和 rs3001371 多态性之间的关联。结果表明，抑郁症患者的自杀意念和焦虑症状与rs2494746多态性之间存在显着关联。另一个 AKT1 多态性 rs3001371 与工作和活动显着相关。与携带 rs3001371-G 等位基因的患者相比，携带 rs3001371-A 等位基因的患者病情明显更严重。因此，AKT1 多态性似乎与抑郁症患者的抑郁严重程度、焦虑症状、工作和活动以及自杀企图有关。
For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.
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DOI：
10.1073/pnas.84.14.5034
发表时间：
1987-07-01
影响因子：
11.1
作者：
STAAL, SP
通讯作者：
STAAL, SP
影响因子：
30.8
作者：
Emamian, ES;Hall, D;Gogos, JA
通讯作者：
Gogos, JA
影响因子：
--
作者：
Kendler, KS;Prescott, CA
通讯作者：
Prescott, CA
影响因子：
--
作者：
Dwivedi, Yogesh;Mondal, Amal C.;Pandey, Ghanshyam N.
通讯作者：
Pandey, Ghanshyam N.
影响因子：
3.2
作者：
Karege, Felicien;Perroud, Nader;Malafosse, Alain
通讯作者：
Malafosse, Alain