Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke.
Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke.
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DOI：
10.1016/j.isci.2023.107920
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发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Miranda RC
中科院分区：
文献类型：
--
作者：
Pinson MR;Bake S;Hurst DA;Samiya NT;Sohrabji F;Miranda RC
产前酒精暴露（PAE）损害成年啮齿动物脑血管缺血性中风的恢复。由于中风后肠道会出现生态不良，我们评估了PAE和肠门炎症之间的联系。成年对照和PAE大鼠后代接受单侧内皮素-1诱导的大脑中动脉闭塞。评估脑卒中后行为障碍和脑细胞因子。对中风暴露和中风初期后代的肠系膜脂肪和肝脏转录组进行了评估。我们发现，在中风初发动物的肝脏中，PAE与炎症性坏死性下垂的基因网络之间存在中度相关性。PAE抑制脑卒中急性期脑炎性细胞因子反应。卒中后神经功能与与b淋巴细胞分化和核因子κB （NF-κB）信号传导相关的脂肪基因网络以及肝脏促炎基因网络相关。总的来说，PAE抑制脑炎症，但在中风后导致肠门静脉组织的炎症特征，这表明PAE在成人发病疾病后持续对肠-脑轴产生不利影响。产前酒精暴露（PAE）加剧急性成人发病疾病的影响PAE促进成人肝脏基底炎症性坏死下垂PAE抑制成人脑血管缺血性卒中时脑细胞因子的反应PAE提高卒中后肠门静脉组织的炎症基因网络；发育神经科学;神经科学;生理学
Prenatal alcohol exposure (PAE) impairs recovery from cerebrovascular ischemic stroke in adult rodents. Since the gut becomes dysbiotic following stroke, we assessed links between PAE and enteric portal inflammation. Adult control and PAE rat offspring received a unilateral endothelin-1-induced occlusion of the middle cerebral artery. Post-stroke behavioral disabilities and brain cytokines were assessed. Mesenteric adipose and liver transcriptomes were assessed from stroke-exposed and stroke-naive offspring. We identified, in the liver of stroke-naive animals, a moderate correlation between PAE and a gene network for inflammatory necroptosis. PAE inhibited the acute-phase brain inflammatory cytokine response to stroke. Post-stroke neurological function was correlated with an adipose gene network associated with B-lymphocyte differentiation and nuclear factor κB (NF-κB) signaling and with a liver pro-inflammatory gene network. Collectively, PAE inhibits brain inflammation but results in an inflammatory signature in enteric portal tissues after stroke, suggesting that PAE persistently and adversely impacts the gut-brain axis following adult-onset disease. Prenatal alcohol exposure (PAE) exacerbates effects of acute adult-onset disease PAE promotes basal inflammatory necroptosis in adult liver PAE inhibits brain cytokine response to cerebrovascular ischemic stroke in adults PAE elevates inflammatory gene networks in enteric portal tissues after stroke Biological sciences; Developmental neuroscience; Neuroscience; Physiology
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
WGCNA：用于加权相关网络分析的 R 包。
影响因子：
3
作者：
Langfelder P;Horvath S
通讯作者：
Horvath S
影响因子：
7.9
作者：
El-Hakim Y;Mani KK;Eldouh A;Pandey S;Grimaldo MT;Dabney A;Pilla R;Sohrabji F
通讯作者：
Sohrabji F
DOI：
10.1111/acer.13277
发表时间：
2017-01
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Bake S;Gardner R;Tingling JD;Miranda RC;Sohrabji F
通讯作者：
Sohrabji F
影响因子：
15.9
作者：
Kreier, F;Fliers, E;Buijs, RM
通讯作者：
Buijs, RM