Hybrid intraoperative imaging techniques in radioguided surgery: present clinical applications and future outlook.
Hybrid intraoperative imaging techniques in radioguided surgery: present clinical applications and future outlook.
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DOI：
10.1007/s40336-017-0235-x
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发表时间：
2017
影响因子：
2.1
通讯作者：
Perkins AC
中科院分区：
文献类型：
--
作者：
Bugby SL;Lees JE;Perkins AC
本综述旨在总结目前在临床上使用和发展的混合模式放射引导技术，并讨论未来可能的研究途径。由于这些方法的新颖性，其临床相关性的证据尚不存在。这篇综述的目的是让核医学从业者了解目前放射引导外科领域的尖端研究，这些研究可能在未来5-10年内进入标准临床实践。混合成像对核医学诊断越来越重要，但直到最近技术的进步，混合成像才被研究用于放射引导手术。这些模式旨在克服外科成像的一些困难，同时保持许多好处，或者提供传统放射引导下外科医生无法获得的全新信息。使用在线参考数据库(Scope us、PubMed)进行了文献回顾。使用这一技术获得的综述文章被挖掘引文以获得进一步的参考文献。总共有2367篇论文被退回，其中425篇适合进一步评估。本文报道了60篇直接与放射引导手术中的混合术中影像有关的文献。在这些论文中，25篇描述了混合成像的临床应用，22篇描述了新的混合探针和示踪剂的发展，13篇描述了未来临床使用的混合技术的发展。伽马-近红外混合荧光被发现是最常见的临床技术，有35篇文章与这些方法相关。其他混合成像包括伽马-亮场成像、伽马-超声波成像、伽马-β成像和β-OCT成像。文中还讨论了术前和术中影像的结合。混合成像技术为临床医生和外科医生在前哨结节检测等过程中定位摄取部位提供了新的可能性。
This review aims to summarise the hybrid modality radioguidance techniques currently in clinical use and development, and to discuss possible future avenues of research. Due to the novelty of these approaches, evidence of their clinical relevance does not yet exist. The purpose of this review is to inform nuclear medicine practitioners of current cutting edge research in radioguided surgery which may enter standard clinical practice within the next 5–10 years. Hybrid imaging is of growing importance to nuclear medicine diagnostics, but it is only with recent advances in technology that hybrid modalities are being investigated for use during radioguided surgery. These modalities aim to overcome some of the difficulties of surgical imaging while maintaining many benefits, or providing entirely new information unavailable to surgeons with traditional radioguidance. A literature review was carried out using online reference databases (Scopus, PubMed). Review articles obtained using this technique were citation mined to obtain further references. In total, 2367 papers were returned, with 425 suitable for further assessment. 60 papers directly related to hybrid intraoperative imaging in radioguided surgery are reported on. Of these papers, 25 described the clinical use of hybrid imaging, 22 described the development of new hybrid probes and tracers, and 13 described the development of hybrid technologies for future clinical use. Hybrid gamma–NIR fluorescence was found to be the most common clinical technique, with 35 papers associated with these modalities. Other hybrid combinations include gamma–bright field imaging, gamma–ultrasound imaging, gamma–β imaging and β–OCT imaging. The combination of preoperative and intraoperative images is also discussed. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as in sentinel node detection.
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