Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology.
Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology.
复制标题
术中影像引导的癌症手术：从当前的荧光分子成像方法到未来的多模态成像技术
作者：
Chi C;Du Y;Ye J;Kou D;Qiu J;Wang J;Tian J;Chen X
癌症是人类健康的主要威胁。利用精准医学进行诊断和治疗有望成为预防癌症发生和进展的有效方法。虽然解剖和功能成像技术，如X线摄影，计算机断层扫描（CT），磁共振成像（MRI）和正电子发射断层扫描（PET）的准确术前诊断发挥了重要作用，在大多数情况下，这些技术不能在术中应用。光学分子成像是一种很有前途的技术，它在肿瘤边缘检测中提供了高度的灵敏度和特异性。此外，现有的临床应用已经证明，光学分子成像是一种强大的术中工具，用于指导外科医生进行精确手术，从而实现根治性切除并提高生存率。然而，光学分子成像方法存在探测深度限制，需要从光学到多模态术中成像方法的进一步突破，以开发更广泛和全面的术中应用。本文就术中光学分子成像技术的发展现状进行综述，重点介绍造影剂和手术导航系统，并对多模态成像技术在术中影像引导肿瘤手术中的应用前景进行展望。
Cancer is a major threat to human health. Diagnosis and treatment using precision medicine is expected to be an effective method for preventing the initiation and progression of cancer. Although anatomical and functional imaging techniques such as radiography, computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) have played an important role for accurate preoperative diagnostics, for the most part these techniques cannot be applied intraoperatively. Optical molecular imaging is a promising technique that provides a high degree of sensitivity and specificity in tumor margin detection. Furthermore, existing clinical applications have proven that optical molecular imaging is a powerful intraoperative tool for guiding surgeons performing precision procedures, thus enabling radical resection and improved survival rates. However, detection depth limitation exists in optical molecular imaging methods and further breakthroughs from optical to multi-modality intraoperative imaging methods are needed to develop more extensive and comprehensive intraoperative applications. Here, we review the current intraoperative optical molecular imaging technologies, focusing on contrast agents and surgical navigation systems, and then discuss the future prospects of multi-modality imaging technology for intraoperative imaging-guided cancer surgery.
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DOI：
10.1186/1758-3284-2-31
发表时间：
2010-10-30
期刊：
Head & neck oncology
影响因子：
--
作者：
Bredell MG
通讯作者：
Bredell MG
影响因子：
3.7
作者：
Chi C;Ye J;Ding H;He D;Huang W;Zhang GJ;Tian J
通讯作者：
Tian J
影响因子：
--
作者：
Tran Cao HS;Kaushal S;Metildi CA;Menen RS;Lee C;Snyder CS;Messer K;Pu M;Luiken GA;Talamini MA;Hoffman RM;Bouvet M
通讯作者：
Bouvet M
影响因子：
2.6
作者：
Day, Kristine E.;Beck, Lauren N.;Deep, Nicholas L.;Kovar, Joy;Zinn, Kurt R.;Rosenthal, Eben L.
通讯作者：
Rosenthal, Eben L.
影响因子：
3.7
作者：
Blum G;Weimer RM;Edgington LE;Adams W;Bogyo M
通讯作者：
Bogyo M