Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.
Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish.
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DOI：
10.1002/dvg.22785
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发表时间：
2014-06
期刊：
影响因子：
1.5
通讯作者：
Hong, Elim
中科院分区：
文献类型：
--
作者：
deCarvalho, Tagide N.;Subedi, Abhignya;Rock, Jason;Harfe, Brian D.;Thisse, Christine;Thisse, Bernard;Halpern, Marnie E.;Hong, Elim
缰核在调节恐惧和奖励通路中的作用引发了人们对这个保守的前脑区域的新兴趣。两侧成对的缰核，每个由内侧/背侧和外侧/腹侧核组成，可以进一步分为离散的子域，其神经元群体，精确的连接和特定的功能还不清楚。另一个复杂的现象是，在许多非哺乳动物物种中，左右缰核显示出明显的形态差异。值得注意的是，斑马鱼幼体的背侧缰提供了一个脊椎动物的遗传模型，以探讨大脑不对称的发展和功能意义。先前的报道已经描述了一些在斑马鱼缰核中表达的基因，无论是以双侧对称的模式还是在大脑的一侧比另一侧更广泛。我们研究的目标是通过描绘基因表达结构域之间的关系，比较幼虫和成虫阶段左右不对称的程度，并确定由神经递质表型定义的潜在功能亚核区域，来生成斑马鱼背缰核的综合地图。虽然缰组织的许多方面似乎与啮齿动物保守，斑马鱼缰也具有独特的属性，可能是其功能的偏侧化。
The role of the habenular nuclei in modulating fear and reward pathways has sparked a renewed interest in this conserved forebrain region. The bilaterally paired habenular nuclei, each consisting of a medial/dorsal and lateral/ventral nucleus, can be further divided into discrete subdomains whose neuronal populations, precise connectivity and specific functions are not well understood. An added complexity is that the left and right habenulae show pronounced morphological differences in many non-mammalian species. Notably, the dorsal habenulae of larval zebrafish provide a vertebrate genetic model to probe the development and functional significance of brain asymmetry. Previous reports have described a number of genes that are expressed in the zebrafish habenulae, either in bilaterally symmetric patterns or more extensively on one side of the brain than the other. The goal of our study was to generate a comprehensive map of the zebrafish dorsal habenular nuclei, by delineating the relationship between gene expression domains, comparing the extent of left-right asymmetry at larval and adult stages, and identifying potentially functional subnuclear regions as defined by neurotransmitter phenotype. While many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions.
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影响因子：
3.6
作者：
Bianco IH;Carl M;Russell C;Clarke JD;Wilson SW
通讯作者：
Wilson SW
缰核：脊椎动物大脑中保守的不对称中继站。
DOI：
10.1098/rstb.2008.0213
发表时间：
2009-04-12
影响因子：
6.3
作者：
Bianco, Isaac H.;Wilson, Stephen W.
通讯作者：
Wilson, Stephen W.
DOI：
10.1002/cne.22171
发表时间：
2009-12-10
期刊：
The Journal of comparative neurology
影响因子：
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作者：
Berman JR;Skariah G;Maro GS;Mignot E;Mourrain P
通讯作者：
Mourrain P
影响因子：
2.5
作者：
BRAITENBERG V;KEMALI M
通讯作者：
KEMALI M
影响因子：
3.7
作者：
Akle V;Guelin E;Yu L;Brassard-Giordano H;Slack BE;Zhdanova IV
通讯作者：
Zhdanova IV