Effects of selected surfactants on purified glucosyltransferases from mutans streptococci and cellular adherence to smooth surfaces.
Effects of selected surfactants on purified glucosyltransferases from mutans streptococci and cellular adherence to smooth surfaces.
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选定的表面活性剂对来自变形链球菌的纯化葡萄糖基转移酶和细胞粘附到光滑表面的影响。
DOI：
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发表时间：
1993
影响因子：
3
通讯作者：
Shigeyuki Hamada
中科院分区：
文献类型：
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作者：
Shigetada Kawabata;M. Torii;T. Minami;T. Fujiwara;Shigeyuki Hamada
研究了非离子型、阴离子型、阳离子型和两性型表面活性剂对变形链球菌MT8148和sobrinus 6715细胞生长的抑制作用，对纯化的葡萄糖基转移酶（GTase）合成葡聚糖的抑制作用，以及对细菌对玻璃表面粘附的抑制作用。阳离子表面活性剂表现出明显的杀菌活性。阴离子和两性化合物的杀菌作用较弱，非离子表面活性剂对细胞生长只有轻微的抑制作用。一些非离子型化合物对此没有影响。阴离子和阳离子表面活性剂抑制变形链球菌GTase合成葡聚糖。在各种GTase蛋白中，不溶性葡聚糖合成GTase，即S. mutans CA-GTase和S. sobrinus GTase- i被这些药物最有效地抑制。然而，我们注意到，低浓度的阳离子表面活性剂增强了这些GTase的活性，而高浓度的表面活性剂则具有抑制作用。非离子型洗涤剂刺激变形链球菌CF-GTase的可溶性葡聚糖合成，而阳离子和两性表面活性剂则根据表面活性剂的浓度增强或抑制葡聚糖合成。变形链球菌静息细胞对玻璃表面的蔗糖依赖性粘附受到表面活性剂的抑制，表面活性剂使GTase活性失效。
The inhibitory effect of non-ionic, anionic, cationic and ampholytic surfactants on cellular growth of Streptococcus mutans MT8148 and S. sobrinus 6715, on glucan synthesis by the purified glucosyltransferase (GTase) from these organisms, and on bacterial adherence to glass surfaces was examined in vitro. Cationic surfactants exhibited marked bactericidal activities. Anionic and ampholytic compounds were less strongly bactericidal and non-ionic surfactants produced only slight inhibition of cell growth under the conditions tested. Some non-ionic compounds had no effect on this. Glucan synthesis by GTase from mutans streptococci was inhibited by anionic and cationic surfactants. Among various GTase proteins, insoluble glucan synthesising GTases, i.e., S. mutans CA-GTase and S. sobrinus GTase-I were those most effectively inhibited by these agents. However, it was noted that whereas lower concentrations of cationic surfactants enhanced these GTase activities, higher concentrations of the surfactants were inhibitory. Non-ionic detergents stimulated soluble glucan synthesis from S. mutans CF-GTase and cationic and ampholytic surfactants enhanced or inhibited glucan synthesis depending on the concentrations of the surfactants. Sucrose-dependent cellular adherence of resting cells of mutans streptococci to glass surfaces was inhibited by the addition of surfactants that annulled the GTase activities.
氟化物和选定的阳离子表面活性剂对啮齿动物龋齿的影响。
影响因子：
4.2
作者：
Tamura,T;Gron,P;Caslavska,V;Kent,R
通讯作者：
Kent,R