BMI and Outcomes of SARS-CoV-2 Among US Veterans.
BMI and Outcomes of SARS-CoV-2 Among US Veterans.
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DOI：
10.1002/oby.23111
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Ioannou GN
中科院分区：
文献类型：
--
作者：
Eastment MC;Berry K;Locke E;Green P;O'Hare A;Crothers K;Dominitz JA;Fan VS;Shah JA;Ioannou GN
在一组退伍军人事务部登记者中检查BMI与SARS-CoV-2检测阳性和不良结局风险的关系。调整后的相对风险/危险比计算BMI类别（体重不足，正常体重，超重，1级肥胖，2级肥胖和3级肥胖）与SARS-CoV-2检测阳性或经历住院，重症监护室（ICU）入院，机械通气和死亡之间的相关性。与正常体重类别相比，较高的BMI类别与SARS-CoV-2检测阳性的较高风险相关（3级肥胖校正的相对风险为1.34，95%置信区间[CI]为1.28-1.42）。在25，952例SARS-CoV-2阳性患者中，与正常体重个体相比，3级肥胖与较高的机械通气风险（校正风险比[aHR] 1.77，95%CI 1.35-2.32）和死亡率（aHR 1.42，95%CI 1.12-1.78）相关。这些关联主要存在于<65岁的患者中，在老年组中减弱或不存在（相互作用p<0.05）。具有较高BMI的VA登记者更有可能检测出SARS-CoV-2阳性，并且如果SARS-CoV-2感染，则更有可能进行机械通气或死亡。与其他年龄组相比，较高的BMI对<65岁人群的死亡风险贡献相对较大。
Examine the associations of BMI with testing positive for SARS-CoV-2 and risk of adverse outcomes in a cohort of Veterans Affairs enrollees. Adjusted relative risks/hazard ratios were calculated for the associations between BMI category (underweight, normal-weight, overweight, class 1 obesity, class 2 obesity, and class 3 obesity) and testing positive for SARS-CoV-2 or experiencing hospitalization, intensive care unit (ICU) admission, mechanical ventilation, and death among those testing positive. Higher BMI categories were associated with higher risk of a positive SARS-CoV-2 test compared to the normal-weight category (class 3 obesity adjusted relative risk 1.34, 95% confidence interval [CI] 1.28–1.42). Among 25,952 SARS-CoV-2-positive patients, class 3 obesity was associated with higher risk of mechanical ventilation (adjusted hazard ratio [aHR] 1.77, 95%CI 1.35–2.32) and mortality (aHR 1.42, 95%CI 1.12–1.78) compared to normal-weight individuals. These associations were present primarily in patients <65 and were attenuated or absent in older age groups (interaction p<0.05). VA enrollees with higher BMI were more likely to test positive for SARS-CoV-2 and were more likely to be mechanically ventilated or die if SARS-CoV-2-infected. Higher BMIs contributed relatively more to the risk of death in those <65 years of age as compared to other age categories.
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DOI：
10.1183/09031936.00185211
发表时间：
2013-04
期刊：
The European respiratory journal
影响因子：
--
作者：
King P;Mortensen EM;Bollinger M;Restrepo MI;Copeland LA;Pugh MJ;Nakashima B;Anzueto A;Hitchcock Noël P
通讯作者：
Hitchcock Noël P
影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
2.6
作者：
Thorpe, RJ;Ferraro, KF
通讯作者：
Ferraro, KF
急性呼吸窘迫综合征中的“肥胖悖论”：Asystematic Resectic和Meta-Analysis。
影响因子：
3.7
作者：
Zhi G;Xin W;Ying W;Guohong X;Shuying L
通讯作者：
Shuying L
影响因子：
8.9
作者：
Phung, D. T.;Wang, Z.;Chu, C.
通讯作者：
Chu, C.