Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.
Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.
复制标题
脂联素基因多态性和脂联素水平与三年期间高血糖的发展独立相关：胰岛素抵抗综合征前瞻性研究的流行病学数据。
作者：
F. Fumeron;R. Aubert;A. Siddiq;D. Betoulle;F. Péan;S. Hadjadj;J. Tichet;E. Wilpart;Marie;B. Balkau;P. Froguel;M. Marre
肥胖和2型糖尿病患者血浆中脂肪细胞衍生肽脂联素浓度降低。脂联素基因位于染色体3q27上，其中一个糖尿病易感位点已被定位。在一些横断面研究中，脂联素基因多态性（单核苷酸多态性[SNPs]）与BMI、胰岛素敏感性和2型糖尿病有关。我们的目的是在一项为期3年的前瞻性研究中评估这些snp在胰岛素抵抗综合征特征发展中的作用，该研究包括来自胰岛素抵抗综合征流行病学数据（DESIR）队列的约4500名法国白种人受试者。对于基线时血糖正常的受试者，3年内成为高血糖（糖尿病或空腹血糖受损）的风险受到两个snp的影响：G-11391A和T45G。对于G-11391A， GA携带者的风险增加（经性别调整的比值比[OR] = 1.60 [95% CI 1.16-2.20]; P = 0.004）。对于T45G， GG携带者T45G增高（OR [vs . TT] = 2.71 [1.31-5.60]; P = 0.007）。3年后，GG受试者的BMI （P = 0.009）和腰臀比（P = 0.007）增加更大。基线时脂联素水平与高血糖的发生相关（P = 0.005），但对高血糖风险的预测作用与脂联素基因型无关。总之，在DESIR研究中，脂联素位点的变化影响体重增加、体脂分布、高血糖的发病以及脂联素水平。脂联素基因snp可能具有几种表型效应，这些效应与代谢综合征的发展共同发生。
The plasma concentration of the adipocyte-derived peptide adiponectin is decreased in patients with obesity and type 2 diabetes. The adiponectin gene is located on chromosome 3q27, where a diabetes susceptibility locus has been mapped. Adiponectin gene polymorphisms (single nucleotide polymorphisms [SNPs]) have been associated with BMI, insulin sensitivity, and type 2 diabetes in some cross-sectional studies. Our aim was to assess the contribution of these SNPs in the development of features of the insulin resistance syndrome in a 3-year prospective study in approximately 4,500 French Caucasian subjects from the Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) cohort. For subjects who were normoglycemic at baseline, the 3-year risk of becoming hyperglycemic (diabetes or impaired fasting glucose) was affected by two SNPs: G-11391A and T45G. For G-11391A, the risk was increased in GA carriers (odds ratio [OR] adjusted for sex [versus GG] = 1.60 [95% CI 1.16-2.20]; P = 0.004). For T45G, it was increased in GG carriers (OR [versus TT] = 2.71 [1.31-5.60]; P = 0.007). After 3 years, GG subjects had a greater increase in BMI (P = 0.009) and waist-to-hip ratio (P = 0.007). Adiponectin levels at baseline were associated with the development of hyperglycemia (P = 0.005), but the predictive effects on the risk for hyperglycemia were independent of adiponectin genotypes. In conclusion, in the DESIR study, variations at the adiponectin locus affect body weight gain, body fat distribution, and onset of hyperglycemia, as well as adiponectin levels. Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome.
影响因子：
5
作者：
Tsao, TS;Lodish, HF;Fruebis, J
通讯作者：
Fruebis, J
DOI：
10.1073/pnas.97.26.14478
发表时间：
2000-12-19
影响因子：
11.1
作者：
Kissebah, AH;Sonnenberg, GE;Comuzzie, AG
通讯作者：
Comuzzie, AG
影响因子：
7.7
作者：
Menzaghi, C;Ercolino, T;Doria, A
通讯作者：
Doria, A