Roadmap to eliminate gastric cancer with Helicobacter pylori eradication and consecutive surveillance in Japan.
Roadmap to eliminate gastric cancer with Helicobacter pylori eradication and consecutive surveillance in Japan.
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DOI：
10.1007/s00535-013-0897-8
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发表时间：
2014-01
影响因子：
6.3
通讯作者：
Sakamoto, Naoya
中科院分区：
文献类型：
--
作者：
Asaka, Masahiro;Kato, Mototsugu;Sakamoto, Naoya
关键词：
在日本，每年死于胃癌的人数约为50，000人，在过去50年中没有变化。迄今为止，由于早期胃癌的预后良好，日本的早期胃癌诊断能力在全世界最高，因此一直致力于通过钡剂X射线和内窥镜检查提高早期胃癌的检出率。在日本，胃癌患者的5年生存率超过60%，远高于欧洲和美国（20%），因为这种对早期胃癌的上级诊断。2013年2月，国家健康保险覆盖幽门螺杆菌根除疗法治疗H。幽门相关性慢性胃炎在日本出现。H.幽门相关性胃炎导致胃和十二指肠溃疡以及胃息肉的发展。因此，提供胃炎的治疗可能会大大降低胃和十二指肠溃疡和息肉的患病率。治疗H.由于幽门相关性胃炎导致萎缩性胃炎和胃癌，日本的健康保险现已涵盖幽门相关性胃炎，因此计划通过利用这一创新来消除胃癌相关死亡的战略。根据这一策略，将对胃炎患者进行H。幽门螺杆菌感染者和阳性者将接受根除治疗，随后进行定期监测。如果这一战略得以实施，日本的胃癌死亡率将在10-20年后大幅下降。
In Japan, the annual number of deaths from gastric cancer is approximately 50,000 and there has been no change over the last 50 years. So far, all efforts have been directed toward improving the detection of early gastric cancer by barium X-ray and endoscopy, since early cancer has a good prognosis, resulting in Japan having the best diagnostic capability for early gastric cancer worldwide. The 5-year survival rate of gastric cancer patients exceeds 60 % in Japan and is much higher than that in Europe and the US (20 %) because of this superior diagnosis of early gastric cancer. In February 2013, national health insurance coverage for Helicobacter pylori eradication therapy to treat H. pylori-associated chronic gastritis became available in Japan. H. pylori-associated gastritis leads to development of gastric and duodenal ulcers and gastric polyps. Therefore, providing treatment for gastritis is likely to substantially decrease the prevalence of both gastric and duodenal ulcers and polyps. Because treatment for H. pylori-associated gastritis, which leads to atrophic gastritis and gastric cancer, is now covered by health insurance in Japan, a strategy to eliminate gastric cancer-related deaths by taking advantage of this innovation was planned. According to this strategy, patients with gastritis will be investigated for H. pylori infection and those who are positive will receive eradication therapy followed by periodic surveillance. If this strategy is implemented, deaths from gastric cancer in Japan will decrease dramatically after 10–20 years.
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影响因子：
4.4
作者：
Asaka, Masahiro;Kato, Mototsugu;Graham, David Y.
通讯作者：
Graham, David Y.
影响因子：
2.9
作者：
Arima, N;Adachi, K;Kinoshita, Y
通讯作者：
Kinoshita, Y
DOI：
10.1093/jnci/djs003
发表时间：
2012-03-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Ma, Jun-Ling;Zhang, Lian;Gail, Mitchell H.
通讯作者：
Gail, Mitchell H.
影响因子：
4.4
作者：
Asaka, M;Sugiyama, T;Graham, DY
通讯作者：
Graham, DY
影响因子：
29.4
作者：
Keates, S;Hitti, YS;Kelly, CP
通讯作者：
Kelly, CP