Enteric Fever Diagnosis: Current Challenges and Future Directions.
Enteric Fever Diagnosis: Current Challenges and Future Directions.
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DOI：
10.3390/pathogens10040410
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发表时间：
2021-04-01
期刊：
影响因子：
--
通讯作者：
Song J
中科院分区：
文献类型：
--
作者：
Neupane DP;Dulal HP;Song J
肠道热是由伤寒和副伤寒沙门氏菌引起的一种危及生命的全身性发热性疾病。伤寒和沙门氏菌。副伤寒）。不幸的是，该疾病的负担仍然很高，主要是由于各种耐药沙门氏菌菌株的全球传播，尽管该领域不断取得进展。准确的诊断对于有效控制疾病至关重要。然而，基于临床表现的肠热病诊断是具有挑战性的，因为与流行地区也流行的其他发热性疾病的症状重叠。目前的实验室检测显示出次优的敏感性和特异性，并且没有诊断方法可用于识别无症状携带者。一些研究项目已经采用系统方法来鉴定用于早期检测和无症状携带者检测的更特异的生物标志物。这篇综述讨论了目前可用的诊断试验的优点和缺点，改进诊断试验的研究进展，以及发现新的理想生物标志物和试验的挑战。
Enteric fever is a life-threatening systemic febrile disease caused by Salmonella enterica serovars Typhi and Paratyphi (S. Typhi and S. Paratyphi). Unfortunately, the burden of the disease remains high primarily due to the global spread of various drug-resistant Salmonella strains despite continuous advancement in the field. An accurate diagnosis is critical for effective control of the disease. However, enteric fever diagnosis based on clinical presentations is challenging due to overlapping symptoms with other febrile illnesses that are also prevalent in endemic areas. Current laboratory tests display suboptimal sensitivity and specificity, and no diagnostic methods are available for identifying asymptomatic carriers. Several research programs have employed systemic approaches to identify more specific biomarkers for early detection and asymptomatic carrier detection. This review discusses the pros and cons of currently available diagnostic tests for enteric fever, the advancement of research toward improved diagnostic tests, and the challenges of discovering new ideal biomarkers and tests.
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影响因子：
6.7
作者：
Baker, Stephen;Hardy, Jonathan;Sanderson, Kenneth E;Quail, Michael;Goodhead, Ian;Kingsley, Robert A;Parkhill, Julian;Stocker, Bruce;Dougan, Gordon
通讯作者：
Dougan, Gordon
影响因子：
2.7
作者：
CLEGG, A;PASSEY, M;SUVE, N
通讯作者：
SUVE, N
影响因子：
--
作者：
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通讯作者：
Ryan, Edward T.
影响因子：
0.2
作者：
Chin, Kai Ling;Redhuan, Nur Eliyana Mohd;Ong, Eugene Boon Beng
通讯作者：
Ong, Eugene Boon Beng
DOI：
10.1084/jem.20151025
发表时间：
2016-05-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Blohmke CJ;Darton TC;Jones C;Suarez NM;Waddington CS;Angus B;Zhou L;Hill J;Clare S;Kane L;Mukhopadhyay S;Schreiber F;Duque-Correa MA;Wright JC;Roumeliotis TI;Yu L;Choudhary JS;Mejias A;Ramilo O;Shanyinde M;Sztein MB;Kingsley RA;Lockhart S;Levine MM;Lynn DJ;Dougan G;Pollard AJ
通讯作者：
Pollard AJ