Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
Co-activation of rhythms during alpha band oscillations as an interictal biomarker of exploding head syndrome
复制标题
α带振荡期间节律的共同激活作为爆炸头综合征的发作间期生物标志物
DOI：
10.1177/0333102420902705
复制
发表时间：
2020
期刊：
影响因子：
4.9
通讯作者：
I. Rosenzweig
中科院分区：
文献类型：
--
作者：
Dimitris Fotis Sakellariou;A. Nesbitt;S. Higgins;S. Beniczky;Jan Rosenzweig;P. Drakatos;N. Gildeh;P. Murphy;B. Kent;A. Williams;M. Kryger;P. Goadsby;G. Leschziner;I. Rosenzweig
背景 爆炸头综合征是一种极少见的良性感觉性副失眠症，但可能会对患者的生活质量和幸福感产生重大影响。爆炸头综合征的发作特点是在睡眠-觉醒或觉醒-睡眠过渡状态下无痛地感知到突然的巨响，但迄今为止，其发病机制仍不清楚。方法和结果 为了弥补目前在潜在病理生理学方面的知识空白，我们对在三级睡眠障碍诊所就诊的爆炸头综合征患者的多导睡眠图记录进行了一项回顾性病例对照研究。通过对整夜脑电图进行宏观结构和事件相关动态频谱分析，研究了发作间期（非发作相关）脑电图生物标志物。在爆炸头综合征患者中，清醒时和睡眠/觉醒时记录到额外的振荡活动。这种活动在频率、地形和来源上都与伴随的阿尔法节律不同。结论 根据这些初步研究结果，我们推测爆炸头综合征患者在睡眠-觉醒转换时，注意力处理的异常可能会导致外部感觉刺激的放大和调节。
Background Exploding head syndrome is a rarely reported benign sensory parasomnia that may nonetheless have significant impact on patients’ quality of life and their perceived well-being. To date, the mechanisms underlying attacks, characterised by a painless perception of abrupt, loud noises at transitional sleep-wake or wake-sleep states, are by and large unclear. Methods and results In order to address the current gap in the knowledge of potential underlying pathophysiology, a retrospective case-control study of polysomnographic recordings of patients presenting to a tertiary sleep disorders clinic with exploding head syndrome was conducted. Interictal (non-attack associated) electroencephalographic biomarkers were investigated by performing macrostructural and event-related dynamic spectral analyses of the whole-night EEG. In patients with exploding head syndrome, additional oscillatory activity was recorded during wakefulness and at sleep/wake periods. This activity differed in its frequency, topography and source from the alpha rhythm that it accompanied. Conclusion Based on these preliminary findings, we hypothesise that at times of sleep-wake transition in patients with exploding head syndrome, aberrant attentional processing may lead to amplification and modulation of external sensory stimuli.
影响因子：
19.9
作者：
Klimesch, Wolfgang
通讯作者：
Klimesch, Wolfgang
影响因子：
5.3
作者：
Herweg, Nora A.;Apitz, Thore;Bunzeck, Nico
通讯作者：
Bunzeck, Nico