Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Vasculopathies and Angiogenesis: Therapeutic Applications and Optimization.
Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Vasculopathies and Angiogenesis: Therapeutic Applications and Optimization.
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DOI：
10.3390/biom13071109
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发表时间：
2023-07-12
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞外小泡(EVS)作为细胞分泌组的一部分，在多种生理和病理过程中发挥着重要的细胞间通讯调节作用。以往的研究广泛报道了间充质基质细胞来源的血管内皮细胞(MSC-EVS)通过促进血管生成在缺血性疾病或再生医学中具有潜在的治疗应用。MSC-EVS还对其他血管病变发挥有益作用，包括动脉粥样硬化、动脉瘤、血管再狭窄、血管钙化、血管渗漏、肺高压和糖尿病视网膜病变。因此，MSC-EVS在调节血管内稳态方面的潜力正引起越来越多的关注。除了天然或裸露的MSC-EVS外，还可以引入改良的MSC-EVS和合适的输送MSC-EVS的生物材料，以进一步促进其治疗应用。在此，我们概述了MSC-EVS在不同血管病变和血管生成中的功能作用，以阐明MSC-EVS如何有助于维持血管系统的动态平衡。我们还讨论了当前优化其治疗效果的策略，这些策略依赖于MSC-EV的卓越生物活性、高产率、高效递送和受控释放到所需区域，以及需要克服的挑战，以允许其广泛的临床翻译。
Extracellular vesicles (EVs), as part of the cellular secretome, have emerged as essential cell–cell communication regulators in multiple physiological and pathological processes. Previous studies have widely reported that mesenchymal stromal cell-derived EVs (MSC-EVs) have potential therapeutic applications in ischemic diseases or regenerative medicine by accelerating angiogenesis. MSC-EVs also exert beneficial effects on other vasculopathies, including atherosclerosis, aneurysm, vascular restenosis, vascular calcification, vascular leakage, pulmonary hypertension, and diabetic retinopathy. Consequently, the potential of MSC-EVs in regulating vascular homeostasis is attracting increasing interest. In addition to native or naked MSC-EVs, modified MSC-EVs and appropriate biomaterials for delivering MSC-EVs can be introduced to this area to further promote their therapeutic applications. Herein, we outline the functional roles of MSC-EVs in different vasculopathies and angiogenesis to elucidate how MSC-EVs contribute to maintaining vascular system homeostasis. We also discuss the current strategies to optimize their therapeutic effects, which depend on the superior bioactivity, high yield, efficient delivery, and controlled release of MSC-EVs to the desired regions, as well as the challenges that need to be overcome to allow their broad clinical translation.
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