Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma.
Cyclin D1 expression predicts postoperative distant metastasis and survival in resectable esophageal squamous cell carcinoma.
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Cyclin D1 表达预测可切除食管鳞状细胞癌术后远处转移和生存
DOI：
10.18632/oncotarget.9078
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发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Yang HX
中科院分区：
文献类型：
--
作者：
Hou X;Liang RB;Wei JC;Xu Y;Fu JH;Luo RZ;He JH;Zhang LJ;Lin P;Yang HX
目的：我们的目的是确定食管鳞癌患者术后转移的风险增加。结果高水平的cyclin D1表达、肿瘤细胞分化差、肿瘤分期较晚均增加了ESCC术后转移的风险，降低了无远处转移生存率。高水平的细胞周期蛋白D1表达也降低了训练组的总生存率（p < 0.01），但在验证组中没有降低（p = 0.415）。然而，当两组患者合并以获得更大的病例数时，高水平的细胞周期蛋白D1表达再次被证明是降低总生存率的独立预测因子（p < 0.01）。方法我们使用来自两个机构的数据建立培训（n = 319）和验证（n = 164）队列。生成组织微阵列用于免疫组织化学评价。分析cyclin D1表达、临床病理变量、术后远处转移、总生存率和无远处转移生存率之间的相关性。采用多因素分析法分析影响术后远处转移和生存的独立因素。然后使用验证队列和汇总数据集对训练队列产生的结果进行测试。结论cyclin D1高表达增加了可切除食管鳞癌的远处转移，降低了总生存率和无远处转移生存率。结合细胞周期蛋白D1的表达、肿瘤细胞分化程度和肿瘤分期，识别术后转移风险增加的患者成为可能。
Purpose We aim to identify esophageal squamous cell carcinoma patients with increased risk of postoperative metastases. Results A high level of cyclin D1 expression, together with poor tumor cell differentiation and advanced tumor stages, increased risk of postoperative metastasis and decreased distant metastasis-free survival in ESCC in both cohorts. A high level of cyclin D1 expression also decreased overall survival in the training cohort (p < 0.01) but not in the validation cohort (p = 0.415). However, when the two cohorts of patients were pooled to obtain a larger case number, a high level of cyclin D1 expression was again demonstrated as an independent predictor that decreased overall survival (p < 0.01). Methods We used data from two institutions to establish training (n = 319) and validation (n = 164) cohorts. Tissue microarrays were generated for immunohistochemical evaluation. The correlation among cyclin D1 expression, clinicopathologic variables, postoperative distant metastases, overall survival, and distant metastasis-free survival were analyzed. Multivariate analyses were used to test the independent factors impacting postoperative distant metastases and survival. The outcomes generated from the training cohort were then tested using the validation cohort and pooled dataset. Conclusions High level of cyclin D1 expression increased distant metastasis, decreased overall survival and distant metastasis-free survival in resectable ESCC. Using a combination of cyclin D1 expression, tumor cell differentiation grade, and tumor stages, identifying patients with increased risk of postoperative metastases becomes possible.
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