Tumor educated platelet: the novel BioSource for cancer detection.
Tumor educated platelet: the novel BioSource for cancer detection.
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DOI：
10.1186/s12935-023-02927-5
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发表时间：
2023-05-11
影响因子：
5.8
通讯作者：
Song, Xingguo
中科院分区：
文献类型：
--
作者：
Ding, Shanshan;Dong, Xiaohan;Song, Xingguo
血小板参与肿瘤发生发展的全过程，在其生命周期内不断在循环中吸收和富集肿瘤特异性物质，因此被称为“肿瘤教育血小板”（Tumor - education Platelets, TEPs）。由于转录后剪接的调节机制，血小板mRNA谱的改变已被确定为肿瘤标志物。小核RNA （snrna）是血小板中重要的剪接体成分，主导血小板RNA剪接并调节pre-mRNA的剪接强度。snRNA水平的内源性变异导致选择性剪接的广泛差异，从而推动肿瘤疾病的发生和进展。本文系统阐述了肿瘤与血小板的双向相互作用，特别是肿瘤诱导的TEP的选择性剪接，并进一步探讨了与选择性剪接相关的snrna等分子是否可以作为癌症诊断的新生物标志物。
Platelets, involved in the whole process of tumorigenesis and development, constantly absorb and enrich tumor-specific substances in the circulation during their life span, thus called “Tumor Educated Platelets” (TEPs). The alterations of platelet mRNA profiles have been identified as tumor markers due to the regulatory mechanism of post-transcriptional splicing. Small nuclear RNAs (SnRNAs), the important spliceosome components in platelets, dominate platelet RNA splicing and regulate the splicing intensity of pre-mRNA. Endogenous variation at the snRNA levels leads to widespread differences in alternative splicing, thereby driving the development and progression of neoplastic diseases. This review systematically expounds the bidirectional tumor-platelets interactions, especially the tumor induced alternative splicing in TEP, and further explores whether molecules related to alternative splicing such as snRNAs can serve as novel biomarkers for cancer diagnostics.
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