Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma.
Correlations Between DCE MRI and Histopathological Parameters in Head and Neck Squamous Cell Carcinoma.
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DOI：
10.1016/j.tranon.2016.10.001
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发表时间：
2017-02
影响因子：
5
通讯作者：
Stumpp P
中科院分区：
文献类型：
--
作者：
Surov A;Meyer HJ;Gawlitza M;Höhn AK;Boehm A;Kahn T;Stumpp P
背景：动态对比增强磁共振成像（DCE MRI）可以表征组织的灌注和血管化。DCE MRI参数可区分良恶性病变，预测肿瘤分级。本研究的目的是将头颈部鳞状细胞癌（HNSCC）的DCE MRI表现与各种组织病理学参数相关联。患者和方法：16例组织学证实的HNSCC患者（11例原发肿瘤和5例局部肿瘤复发）纳入研究。所有病例均行DCE成像，并估计以下参数：Ktrans、Ve、Kep和iAUC。在Ki 67抗原染色的标本上估计肿瘤增殖指数。在CD31抗原染色标本上估计微血管密度参数（染色血管面积、总血管面积、血管数量、平均血管直径）。计算DCE与不同组织病理参数之间的Spearman非参数秩和相关系数。结果：DCE灌注参数平均值为：Ktrans 0.189±0.056 min−1,Kep 0.390±0.160 min−1,Ve 0.548±0.119%,iAUC 22.40±12.57。Kep与染色血管面积（r = 0.51, P = 0.041）和总血管面积（r = 0.5118, P = 0.043）呈显著相关；Ve与平均血管直径之间的差异（r = - 0.59, P = 0.017）。细胞计数倾向于与Ve相关（r = - 0.48, P = 0.058）。仅在原发性HNSCC的分析中，Ktrans和ki67之间存在显著的负相关（r = - 0.62, P = 0.041）。我们的分析显示，在HNSCC中，DCE参数与组织病理学结果之间存在显著相关性。
BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) can characterize perfusion and vascularization of tissues. DCE MRI parameters can differentiate between malignant and benign lesions and predict tumor grading. The purpose of this study was to correlate DCE MRI findings and various histopathological parameters in head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: Sixteen patients with histologically proven HNSCC (11 cases primary tumors and in 5 patients with local tumor recurrence) were included in the study. DCE imaging was performed in all cases and the following parameters were estimated: Ktrans, Ve, Kep, and iAUC. The tumor proliferation index was estimated on Ki 67 antigen stained specimens. Microvessel density parameters (stained vessel area, total vessel area, number of vessels, and mean vessel diameter) were estimated on CD31 antigen stained specimens. Spearman's non-parametric rank sum correlation coefficients were calculated between DCE and different histopathological parameters. RESULTS: The mean values of DCE perfusion parameters were as follows: Ktrans 0.189 ± 0.056 min−1, Kep 0.390 ± 0.160 min−1, Ve 0.548 ± 0.119%, and iAUC 22.40 ± 12.57. Significant correlations were observed between Kep and stained vessel areas (r = 0.51, P = .041) and total vessel areas (r = 0.5118, P = .043); between Ve and mean vessel diameter (r = −0.59, P = .017). Cell count had a tendency to correlate with Ve (r = −0.48, P = .058). In an analysis of the primary HNSCC only, a significant inverse correlation between Ktrans and KI 67 was identified (r = −0.62, P = .041). Our analysis showed significant correlations between DCE parameters and histopathological findings in HNSCC.
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影响因子：
3.3
作者：
Aryal, Madhava P.;Nagaraja, Tavarekere N.;Keenan, Kelly A.;Bagher-Ebadian, Hassan;Panda, Swayamprava;Brown, Stephen L.;Cabral, Glauber;Fenstermacher, Joseph D.;Ewing, James R.
通讯作者：
Ewing, James R.
影响因子：
5.9
作者：
van Niekerk, Cornelis G.;van der Laak, Jeroen A. W. M.;Hulsbergen-van de Kaa, Christina A.
通讯作者：
Hulsbergen-van de Kaa, Christina A.
影响因子：
2.1
作者：
Puech, Philippe;Potiron, Eric;Villers, Arnauld
通讯作者：
Villers, Arnauld
影响因子：
5.7
作者：
Andersen, Erlend K. F.;Hole, Knut Hakon;Malinen, Eirik
通讯作者：
Malinen, Eirik
影响因子：
2.1
作者：
Cho, Eunkyung;Chung, Dong Jin;Hahn, Sung-Tae
通讯作者：
Hahn, Sung-Tae