Application of a WeChat-based mini-app as a patient reminder in Helicobacter pylori eradication: a prospective multi-center randomized controlled study.
Application of a WeChat-based mini-app as a patient reminder in Helicobacter pylori eradication: a prospective multi-center randomized controlled study.
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DOI：
10.1186/s12876-022-02614-1
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发表时间：
2022-12-16
影响因子：
2.4
通讯作者：
Li, Lan
中科院分区：
文献类型：
--
作者：
Sun, Kefang;Chen, Yishu;Wang, Zhenzhen;Liu, Yi;Pan, Yue;Mao, Xinli;Xu, Lei;Jin, Chaohui;Chen, Ming;Yu, Chaohui;Li, Lan
为了提高幽门螺杆菌的根除率，研究人员研究了基于微信的小程序作为电子提醒系统在幽门螺杆菌治疗中的作用。来自三个医疗中心的受试者被分为两组。基于每日小应用程序的通知系统组中的患者通过微信小应用程序收到每日通知。对照组患者在第一次临床就诊时接受一次性口头教育。两组均接受为期 14 天的四联疗法以根除幽门螺杆菌感染。评估了根除率、依从性、不良事件和满意度。进行了意向治疗（ITT）和符合方案（PP）分析。与对照组相比，每日小程序通知系统组的根除率略高（ITT 分析：76.70% vs. 70.73%，p = 0.312；PP 分析：85.87% vs. 82.86%，p = 0.562）。基于每日小应用程序的通知系统组的依从性显着较高（ITT 分析：85.52% vs. 70.48%，p = 0.028；PP 分析：92.39% vs. 81.90%，p = 0.030）。两组之间的不良事件发生率相似（PP 分析：36.96% vs. 40.95%，p = 0.566）。在按年龄、居住地、教育程度或内窥镜检查结果进行的每个亚组分析中，根除率没有显着差异。研究表明，基于迷你应用程序的每日通知提高了患者的依从性，但没有提高幽门螺杆菌根除率。试验注册该研究已在中国临床试验注册中心注册（ChiCTR2000031011，21/03/2020）。在线版本包含可在 10.1186/s12876-022-02614-1 获取的补充材料。
To improve the eradication rate of H. pylori, researchers have investigated the role of WeChat-based mini-app as an electronic reminding system in H. pylori treatment. Subjects from three medical centers were divided into two groups. Patients in the daily mini-app-based notification system group received daily notifications via the WeChat mini-app. Patients in the control group received one-time verbal education on the first clinical visit. Both groups received a 14-day quadruple therapy to eradicate H. pylori infection. Eradication rate, compliance, adverse events and satisfaction were evaluated. Both intention-to-treat (ITT) and per-protocol (PP) analyses were conducted. The eradication rate in the daily mini-app-based notification system group was slightly higher compared with the control group (ITT analysis: 76.70% vs. 70.73%, p = 0.312; PP analysis: 85.87% vs. 82.86%, p = 0.562). The compliance was significantly higher in the daily mini-app-based notification system group (ITT analysis: 85.52% vs. 70.48%, p = 0.028; PP analysis: 92.39% vs. 81.90%, p = 0.030). The adverse event rates were similar between the two groups (PP analysis: 36.96% vs. 40.95%, p = 0.566). No significant difference in eradication rate was seen in each subgroup analysis by age, place of residence, grade of education, or endoscopic findings. The study showed that daily mini-app-based notification improved patient compliance but not H. pylori eradication rate. Trial registration The research was registered in the Chinese Clinical Trial Registry (ChiCTR2000031011, 21/03/2020). The online version contains supplementary material available at 10.1186/s12876-022-02614-1.
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影响因子：
29.4
作者：
Savoldi A;Carrara E;Graham DY;Conti M;Tacconelli E
通讯作者：
Tacconelli E
影响因子：
4.4
作者：
Liu, Wen Zhong;Xie, Yong;Lu, Nong Hua
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Lu, Nong Hua
铋剂、兰索拉唑、阿莫西林和甲硝唑或克拉霉素作为幽门螺杆菌一线治疗
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Lu, Hong
影响因子：
5.5
作者：
Sutton P;Boag JM
通讯作者：
Boag JM
影响因子：
4.4
作者：
Luo, Miaomiao;Hao, Yu;Chen, Weigang
通讯作者：
Chen, Weigang