IsoQuant: a software tool for stable isotope labeling by amino acids in cell culture-based mass spectrometry quantitation.
IsoQuant: a software tool for stable isotope labeling by amino acids in cell culture-based mass spectrometry quantitation.
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Isoquant：一种用于基于细胞培养的质谱定量中氨基酸标记稳定同位素标记的软件工具。
DOI：
10.1021/ac300510t
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发表时间：
2012-05-15
影响因子：
7.4
通讯作者：
Yang, Austin J.
中科院分区：
文献类型：
--
作者：
Liao, Zhongping;Wan, Yunhu;Thomas, Stefani N.;Yang, Austin J.
Accurate protein identification and quantitation are critical when interpreting the biological relevance of large-scale shotgun proteomics datasets. Although significant technical advances in peptide and protein identification have been made, accurate quantitation of high throughput datasets remains a key challenge in mass spectrometry data analysis and is a labor intensive process for many proteomics laboratories. Here, we report a new SILAC-based proteomics quantitation software tool, named IsoQuant, which is used to process high mass accuracy mass spectrometry data. IsoQuant offers a convenient quantitation framework to calculate peptide/protein relative abundance ratios. At the same time, it also includes a visualization platform that permits users to validate the quality of SILAC peptide and protein ratios. The program is written in the C# programming language under the Microsoft .NET framework version 4.0 and has been tested to be compatible with both 32-bit and 64-bit Windows 7. It is freely available to non-commercial users at http://www.proteomeumb.org/MZw.html.
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