Potential role of sirtuin as a therapeutic target for neurodegenerative diseases.
Potential role of sirtuin as a therapeutic target for neurodegenerative diseases.
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DOI：
10.3988/jcn.2009.5.3.120
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Han SH
中科院分区：
文献类型：
--
作者：
Han SH
Sirtuins(Sirtuins)是一种蛋白质修饰酶，普遍存在于所有生物体中。SIRT1是酵母烟酰胺腺嘌呤二核苷酸依赖的脱乙酰酶沉默信息调节因子2(Sir2)的哺乳动物同源物，Sir2是SIRT家族中最具特征的成员。它在几种模式生物中调节寿命，并参与哺乳动物细胞的几个过程，包括细胞生存、分化和新陈代谢。SIRT1的诱导，无论是白藜芦醇等SIRT激活化合物的诱导，还是与热量限制相关的代谢调节，都可能具有神经保护作用，从而延缓神经退化过程，从而延长寿命。然而，激活SIRT和延长人类健康衰老或延缓与年龄相关的疾病之间的确切机制联系尚未建立。
The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent deacetylase silent information regulator 2 (known as Sir2), which is the best-characterized SIRT family member. It regulates longevity in several model organisms and is involved in several processes in mammalian cells including cell survival, differentiation, and metabolism. SIRT1 induction, either by SIRT-activating compounds such as resveratrol, or metabolic conditioning associated with caloric restriction, could have neuroprotective qualities and thus delay the neurodegenerative process, thereby promoting longevity. However, the precise mechanistic liaison between the activation of SIRT and extended healthy aging or delaying age-related diseases in humans has yet to be established.
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