Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling.
Methylation of HBP1 by PRMT1 promotes tumor progression by regulating actin cytoskeleton remodeling.
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PRMT1 对 HBP1 的甲基化通过调节肌动蛋白细胞骨架重塑促进肿瘤进展
DOI：
10.1038/s41389-022-00421-7
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发表时间：
2022-08-08
期刊：
影响因子：
6.2
通讯作者：
Zhang, Xiaowei
中科院分区：
文献类型：
--
作者：
Wang, Jiyin;Yang, Ruixiang;Cheng, Yuning;Zhou, Yue;Zhang, Tongjia;Wang, Shujie;Li, Hui;Jiang, Wei;Zhang, Xiaowei
HBP1 is a sequence-specific transcription factor which generally considered as a crucial growth inhibitor. Posttranslational modification of HBP1 is vital for its function. In this study, we demonstrate that HBP1 is methylated at R378 by PRMT1, which decreases HBP1 protein stability by promoting its ubiquitination and proteasome-mediated degradation. PRMT1-mediated methylation of HBP1 alleviates the repressive effects of HBP1 on tumor metastasis and growth.GSNis identified as a novel target gene of HBP1. Methylation of HBP1 promotes actin cytoskeleton remodeling, glycolysis and tumor progression by downregulating GSN (a vital actin-binding protein) levels. The methylated HBP1-GSN axis is associated with the clinical outcomes of cancer patients. This investigation elucidates the mechanism of how methylated HBP1 facilitates actin cytoskeleton remodeling, thus attenuates its tumor-suppressive function and promotes tumor progression. Targeting methylated HBP1-GSN axis may provide a therapeutic strategy for cancer.
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影响因子：
8
作者：
Claeys, Shana;Denecker, Geertrui;Speleman, Frank
通讯作者：
Speleman, Frank
DOI：
10.1074/jbc.m114.636050
发表时间：
2015-05-22
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Avasarala S;Van Scoyk M;Karuppusamy Rathinam MK;Zerayesus S;Zhao X;Zhang W;Pergande MR;Borgia JA;DeGregori J;Port JD;Winn RA;Bikkavilli RK
通讯作者：
Bikkavilli RK
MDM2 通过泛素化转录因子 HBP1 促进基因组不稳定
影响因子：
8
作者：
Cao, Zhengyi .;Xue, Junhui;Zhang, Xiaowei
通讯作者：
Zhang, Xiaowei
影响因子：
44.1
作者：
通讯作者：
--
影响因子：
16
作者：
Bedford, Mark T.;Clarke, Steven G.
通讯作者：
Clarke, Steven G.