Hippocampal theta sequences reflect current goals.
Hippocampal theta sequences reflect current goals.
复制标题
海马theta序列反映了当前的目标。
DOI：
10.1038/nn.3909
复制
发表时间：
2015-02
影响因子：
25
通讯作者：
Redish, A. David
中科院分区：
文献类型：
--
作者：
Wikenheiser, Andrew M.;Redish, A. David
海马区的信息处理被振荡离散化，位置细胞的整体活动被组织成以theta循环为边界的时间序列。Theta序列代表了时间压缩的空间轨迹。它们的前瞻性使它们成为计划未来轨迹的直观候选机制，但它们与目标导向行为的联系尚不清楚。当老鼠执行价值引导的决策任务时，根据老鼠的目标，theta序列在动物当前位置之前投射的程度随时间的不同而变化。前瞻在通往遥远目标的旅途中比在通往更近的目标的旅途中延伸得更远，并且可以预测动物的目的地。然而，当到达目标时，无论动物从哪里开始它的旅程，向前看都是相似的。综上所述，这些结果提供了证据，表明海马theta序列包含与目标或意图相关的信息，指向了规划的潜在空间基础。
Hippocampal information processing is discretized by oscillations, and the ensemble activity of place cells is organized into temporal sequences bounded by theta cycles. Theta sequences represent time-compressed trajectories through space. Their forward-directed nature makes them an intuitive candidate mechanism for planning future trajectories, but their connection to goal-directed behavior remains unclear. As rats performed a value-guided decision-making task, the extent to which theta sequences projected ahead of the animal’s current location varied on a moment-by-moment basis depending on the rat’s goals. Look-ahead extended farther on journeys to distant goals than on journeys to more proximal goals and was predictive of the animal’s destination. On arrival at goals, however, look-ahead was similar regardless of where the animal began its journey from. Together, these results provide evidence that hippocampal theta sequences contain information related to goals or intentions, pointing toward a potential spatial basis for planning.
登录
查看更多内容
影响因子：
4.3
作者：
Bornstein AM;Daw ND
通讯作者：
Daw ND
θ-γ神经代码。
影响因子：
16.2
作者：
Lisman JE;Jensen O
通讯作者：
Jensen O
DOI：
10.1126/science.1189664
发表时间：
2010-09-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Branco T;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
3.5
作者：
Foster, David J.;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
3.5
作者：
Hyman JM;Zilli EA;Paley AM;Hasselmo ME
通讯作者：
Hasselmo ME