Does the feedback of blood results in observational studies influence response and consent? A randomised study of the Understanding Society Innovation Panel.
Does the feedback of blood results in observational studies influence response and consent? A randomised study of the Understanding Society Innovation Panel.
复制标题
DOI：
10.1186/s12874-023-01948-y
复制
发表时间：
2023-06-07
影响因子：
4
通讯作者：
Kumari, Meena
中科院分区：
文献类型：
--
作者：
Benzeval, Michaela;Andrayas, Alexandria;Mazza, Jan;Al Baghal, Tarek;Burton, Jonathan;Crossley, Thomas F.;Kumari, Meena
虽然医学研究通常向参与者提供健康反馈，但在观察性研究中，由于后勤和财政困难，或担心观察到的行为发生变化，情况并不总是如此。然而，有证据表明，缺乏反馈可能会阻止参与者提供生物样本。本文研究了血液结果反馈对参与生物计量样本采集的影响。来自一项纵向研究--理解社会创新小组--的16岁及以上的参与者被随机分成三组--护士面试者、面试者和网络调查--并被邀请参与生物测量数据收集。在每一只手臂中，他们被随机接受他们的血液结果的反馈。对于那些接受护士采访的人，在采访中同时采集了静脉和干血样本(DBS)。对于另外两个手臂，他们被问及是否愿意采集样本，以及他们是否同意留下或发送DBS试剂盒给他们，以便参与者可以提取自己的样本并返回。对血液样本进行了分析，如果是在反馈臂中，参与者将被发送他们的总胆固醇和HbA1c结果。对反馈组和非反馈组的回复率进行了比较：总体上；在研究的每个方面；按社会人口学和健康特征；以及按以前的研究参与情况。建立了反馈组提供血样和控制混杂因素的数据收集方法的Logistic回归模型。总共有2162人(80.3%的受访家庭)参与了调查，其中1053人(48.7%)同意提供血液样本。提供反馈对总体参与几乎没有影响，但确实增加了对提供血液样本的同意(未调整的OR 1.38；CI：1.16-1.64)。控制参与者特征，反馈的效果在网络参与者中最高(1.55；1.11-2.17)，其次是访谈参与者(1.35；0.99-1.84)，然后是护士访谈参与者(1.30；0.89-1.92)。提供血液结果的反馈增加了提供样本的意愿，特别是对于那些参与网络调查的人。
While medical studies generally provide health feedback to participants, in observational studies this is not always the case due to logistical and financial difficulties, or concerns about changing observed behaviours. However, evidence suggests that lack of feedback may deter participants from providing biological samples. This paper investigates the effect of offering feedback of blood results on participation in biomeasure sample collection. Participants aged 16 and over from a longitudinal study – the Understanding Society Innovation Panel—were randomised to three arms – nurse interviewer, interviewer, web survey – and invited to participate in biomeasures data collection. Within each arm they were randomised to receive feedback of their blood results or not. For those interviewed by a nurse both venous and dried blood samples (DBS) were taken in the interview. For the other two arms, they were asked if they would be willing to take a sample, and if they agreed a DBS kit was left or sent to them so the participant could take their own sample and return it. Blood samples were analysed and, if in the feedback arms, participants were sent their total cholesterol and HbA1c results. Response rates for feedback and non-feedback groups were compared: overall; in each arm of the study; by socio-demographic and health characteristics; and by previous study participation. Logistic regression models of providing a blood sample by feedback group and data collection approach controlling for confounders were calculated. Overall 2162 (80.3% of individuals in responding households) took part in the survey; of those 1053 (48.7%) consented to provide a blood sample. Being offered feedback had little effect on overall participation but did increase consent to provide a blood sample (unadjusted OR 1.38; CI: 1.16–1.64). Controlling for participant characteristics, the effect of feedback was highest among web participants (1.55; 1.11–2.17), followed by interview participants (1.35; 0.99 –1.84) and then nurse interview participants (1.30; 0.89–1.92). Offering feedback of blood results increased willingness to give samples, especially for those taking part in a web survey.
登录
查看更多内容
DOI：
10.1525/jer.2012.7.3.84
发表时间：
2012-07-01
影响因子：
1.3
作者：
Hunter, Jennifer;Corcoran, Katherine;Phelps, Kerryn
通讯作者：
Phelps, Kerryn
影响因子：
4.8
作者：
Merz, Sibille;Jaehn, Philipp;Pischon, Tobias;Fischer, Beate;Wirkner, Kerstin;Rach, Stefan;Guenther, Kathrin;Obi, Nadia;Holmberg, Christine;AdvanceGender Study Grp
通讯作者：
AdvanceGender Study Grp
影响因子：
15.8
作者：
Wills AK;Lawlor DA;Matthews FE;Sayer AA;Bakra E;Ben-Shlomo Y;Benzeval M;Brunner E;Cooper R;Kivimaki M;Kuh D;Muniz-Terrera G;Hardy R
通讯作者：
Hardy R
影响因子：
105.7
作者：
Dixon-Woods, M;Jackson, C;Kenyon, S
通讯作者：
Kenyon, S
影响因子：
4
作者：
Lorimer, Karen;Gray, Cindy M.;Benzeval, Michaela
通讯作者：
Benzeval, Michaela