Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation.
Diverse roles of leptin in the gastrointestinal tract: modulation of motility, absorption, growth, and inflammation.
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DOI：
10.1016/j.nut.2010.07.004
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Ziegler TR
中科院分区：
文献类型：
--
作者：
Yarandi SS;Hebbar G;Sauer CG;Cole CR;Ziegler TR
瘦素是在1994年被发现的一种由脂肪组织产生的激素，对摄食行为和体重控制具有调节作用。最近，胃已被确定为瘦素的重要来源，越来越多的证据表明瘦素在胃肠道中具有多种功能。以瘦素为关键词检索PubMed，共检索到17 000余篇文献，其中500余篇与瘦素在胃肠道中的作用相关。对现有摘要进行了审查，并对200多篇原始文章进行了详细审查。现有的文献表明，瘦素可以调节胃肠道的几个重要功能。瘦素与迷走神经和胆囊收缩素相互作用以延迟胃排空，并且对小肠运动具有复杂的影响。瘦素在生理和病理状态下不同地调节胃肠道大量营养素的吸收。在生理状态下，外源性瘦素已被证明可以减少碳水化合物的吸收，并通过PepT 1二肽/三肽转运蛋白增加小肽的吸收。在某些病理状态下，瘦素已被证明可以增加碳水化合物、蛋白质和脂肪的吸收。瘦素在炎症性肠病患者的结肠粘膜中表达上调。瘦素刺激肠粘膜细胞增殖并抑制细胞凋亡。这些功能导致了关于瘦素在胃肠道肿瘤发生中的作用的推测，瘦素的多重免疫调节作用使胃肠道肿瘤发生复杂化。瘦素是胃肠道功能主要方面的重要调节剂，独立于其在食欲调节和肥胖中的更好描述的作用。
Leptin was discovered in 1994 as a hormone produced by adipose tissue with a modulatory effect on feeding behavior and weight control. Recently, the stomach has been identified as an important source of leptin and growing evidence has shown diverse functions for leptin in the gastrointestinal tract. Using leptin as a keyword in PubMed, more than 17 000 articles were identified, of which more than 500 articles were related to the role of leptin in the gastrointestinal tract. Available abstracts were reviewed and more than 200 original articles were reviewed in detail. The available literature demonstrated that leptin can modulate several important functions of the gastrointestinal tract. Leptin interacts with the vagus nerve and cholecystokinin to delay gastric emptying and has a complex effect on motility of the small bowel. Leptin modulates absorption of macronutrients in the gastrointestinal tract differentially in physiologic and pathologic states. In physiologic states, exogenous leptin has been shown to decrease carbohydrate absorption and to increase the absorption of small peptides by the PepT1 di-/tripeptide transporter. In certain pathologic states, leptin has been shown to increase absorption of carbohydrates, proteins, and fat. Leptin has been shown to be upregulated in the colonic mucosa in patients with inflammatory bowel disease. Leptin stimulates gut mucosal cell proliferation and inhibits apoptosis. These functions have led to speculation about the role of leptin in tumorigenesis in the gastrointestinal tract, which is complicated by the multiple immunoregulatory effects of leptin. Leptin is an important modulator of major aspects of gastrointestinal tract functions, independent of its more well-described roles in appetite regulation and obesity.
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影响因子：
3
作者：
Çakir, B;Bozkurt, A;Yegen, BÇ
通讯作者：
Yegen, BÇ
DOI：
10.1152/ajpregu.2001.281.3.r753
发表时间：
2001-09-01
影响因子：
2.8
作者：
Doi, T;Liu, M;Tso, P
通讯作者：
Tso, P
DOI：
10.1152/ajpgi.00334.2005
发表时间：
2006-02-01
影响因子：
4.5
作者：
Cammisotto, PG;Gingras, D;Bendayan, M
通讯作者：
Bendayan, M
影响因子：
32.4
作者：
De Rosa, Veronica;Procaccini, Claudio;Matarese, Giuseppe
通讯作者：
Matarese, Giuseppe
影响因子：
11.2
作者：
Abolhassani, Mohammad;Aloulou, Nijez;Sobhani, Iradj
通讯作者：
Sobhani, Iradj