Effect of endplate calcification and mechanical deformation on the distribution of glucose in intervertebral disc: a 3D finite element study.
Effect of endplate calcification and mechanical deformation on the distribution of glucose in intervertebral disc: a 3D finite element study.
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DOI：
10.1080/10255842.2010.535815
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发表时间：
2011-02
影响因子：
1.6
通讯作者：
Gu WY
中科院分区：
文献类型：
--
作者：
Jackson AR;Huang CY;Gu WY
椎间盘（IVD）是无血管的，从周围血管系统接受营养。理论模型可以补充实验结果，以更清楚地了解营养对IVD。开发了一种新的IVD 3D有限元模型，以研究终板钙化和机械变形对IVD中葡萄糖分布的影响。该模型包括解剖盘几何形状，非线性耦合的细胞代谢与pH值和氧浓度，和应变依赖性的细胞外基质的属性。通过降低终板渗透性（~79%）模拟钙化。在从仰卧位到站立位的转换过程中，根据体内椎间盘变形施加机械载荷。三个静态应变条件被认为是：仰卧，站立，和负重站立。终板钙化导致最低血糖浓度下降45%，而椎间盘变形导致最低血糖浓度下降4.8-63%，这取决于终板情况（即，正常与钙化）。此外，与纤维环区域相比，钙化更强烈地影响细胞核中的葡萄糖浓度。这项研究提供了重要的洞察营养分布下的IVD机械变形。
The intervertebral disc (IVD) is avascular, receiving nutrition from surrounding vasculature. Theoretical modelling can supplement experimental results to understand nutrition to IVD more clearly. A new, 3D finite element model of the IVD was developed to investigate effects of endplate calcification and mechanical deformation on glucose distributions in IVD. The model included anatomical disc geometry, non-linear coupling of cellular metabolism with pH and oxygen concentration, and strain-dependent properties of the extracellular matrix. Calcification was simulated by reducing endplate permeability (~79%). Mechanical loading was applied based on in vivo disc deformation during the transition from supine to standing positions. Three static strain conditions were considered: supine, standing, and weight-bearing standing. Minimum glucose concentrations decreased 45% with endplate calcification, while disc deformation led to a 4.8–63% decrease, depending on the endplate condition (i.e,. normal vs. calcified). Furthermore, calcification more strongly affected glucose concentrations in the nucleus compared to the annulus fibrous region. This study provides important insight into nutrient distributions in IVD under mechanical deformation.
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影响因子：
3.8
作者：
Gu, WY;Yao, H;Flagler, D
通讯作者：
Flagler, D
影响因子：
2.8
作者：
Ishihara, H;Urban, JPG
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Urban, JPG
影响因子：
3
作者：
Bibby, SRS;Jones, DA;Urban, JPG
通讯作者：
Urban, JPG
影响因子：
3
作者：
BERNICK, S;CAILLIET, R
通讯作者：
CAILLIET, R
影响因子：
2.8
作者：
Iatridis, JC;Kumar, S;Mow, VC
通讯作者：
Mow, VC