Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
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DOI：
10.1038/s41418-023-01153-w
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发表时间：
2023-05
影响因子：
12.4
通讯作者：
Galluzzi, Lorenzo
中科院分区：
文献类型：
--
作者：
Vitale, Ilio;Pietrocola, Federico;Guilbaud, Emma;Aaronson, Stuart A.;Abrams, John M.;Adam, Dieter;Agostini, Massimiliano;Agostinis, Patrizia;Alnemri, Emad S.;Altucci, Lucia;Amelio, Ivano;Andrews, David W.;Aqeilan, Rami, I;Arama, Eli;Baehrecke, Eric H.;Balachandran, Siddharth;Bano, Daniele;Barlev, Nickolai A.;Bartek, Jiri;Bazan, Nicolas G.;Becker, Christoph;Bernassola, Francesca;Bertrand, Mathieu J. M.;Bianchi, Marco E.;Blagosklonny, Mikhail V.;Blander, J. Magarian;Blandino, Giovanni;Blomgren, Klas;Borner, Christoph;Bortner, Carl D.;Bove, Pierluigi;Boya, Patricia;Brenner, Catherine;Broz, Petr;Brunner, Thomas;Damgaard, Rune Busk;Calin, George A.;Campanella, Michelangelo;Candi, Eleonora;Carbone, Michele;Carmona-Gutierrez, Didac;Cecconi, Francesco;Chan, Francis K-M;Chen, Guo-Qiang;Chen, Quan;Chen, Youhai H.;Cheng, Emily H.;Chipuk, Jerry E.;Cidlowski, John A.;Ciechanover, Aaron;Ciliberto, Gennaro;Conrad, Marcus;Cubillos-Ruiz, Juan R.;Czabotar, Peter E.;D'Angiolella, Vincenzo;Daugaard, Mads;Dawson, Ted M.;Dawson, Valina L.;De Maria, Ruggero;De Strooper, Bart;Debatin, Klaus-Michael;Deberardinis, Ralph J.;Degterev, Alexei;Del Sal, Giannino;Deshmukh, Mohanish;Di Virgilio, Francesco;Diederich, Marc;Dixon, Scott J.;Dynlacht, Brian D.;El-Deiry, Wafik S.;Elrod, John W.;Engeland, Kurt;Fimia, Gian Maria;Galassi, Claudia;Ganini, Carlo;Garcia-Saez, Ana J.;Garg, Abhishek D.;Garrido, Carmen;Gavathiotis, Evripidis;Gerlic, Motti;Ghosh, Sourav;Green, Douglas R.;Greene, Lloyd A.;Gronemeyer, Hinrich;Haecker, Georg;Hajnoczky, Gyorgy;Hardwick, J. Marie;Haupt, Ygal;He, Sudan;Heery, David M.;Hengartner, Michael O.;Hetz, Claudio;Hildeman, David A.;Ichijo, Hidenori;Inoue, Satoshi;Jaeaettelae, Marja;Janic, Ana;Joseph, Bertrand;Jost, Philipp J.;Kanneganti, Thirumala-Devi;Karin, Michael;Kashkar, Hamid;Kaufmann, Thomas;Kelly, Gemma L.;Kepp, Oliver;Kimchi, Adi;Kitsis, Richard N.;Klionsky, Daniel J.;Kluck, Ruth;Krysko, Dmitri, V;Kulms, Dagmar;Kumar, Sharad;Lavandero, Sergio;Lavrik, Inna N.;Lemasters, John J.;Liccardi, Gianmaria;Linkermann, Andreas;Lipton, Stuart A.;Lockshin, Richard A.;Lopez-Otin, Carlos;Luedde, Tom;MacFarlane, Marion;Madeo, Frank;Malorni, Walter;Manic, Gwenola;Mantovani, Roberto;Marchi, Saverio;Marine, Jean-Christophe;Martin, Seamus J.;Martinou, Jean-Claude;Mastroberardino, Pier G.;Medema, Jan Paul;Mehlen, Patrick;Meier, Pascal;Melino, Gerry;Melino, Sonia;Miao, Edward A.;Moll, Ute M.;Munoz-Pinedo, Cristina;Murphy, Daniel J.;Niklison-Chirou, Maria Victoria;Novelli, Flavia;Nunez, Gabriel;Oberst, Andrew;Ofengeim, Dimitry;Opferman, Joseph T.;Oren, Moshe;Pagano, Michele;Panaretakis, Theocharis;Pasparakis, Manolis;Penninger, Josef M.;Pentimalli, Francesca;Pereira, David M.;Pervaiz, Shazib;Peter, Marcus E.;Pinton, Paolo;Porta, Giovanni;Prehn, Jochen H. M.;Puthalakath, Hamsa;Rabinovich, Gabriel A.;Rajalingam, Krishnaraj;Ravichandran, Kodi S.;Rehm, Markus;Ricci, Jean-Ehrland;Rizzuto, Rosario;Robinson, Nirmal;Rodrigues, Cecilia M. P.;Rotblat, Barak;Rothlin, Carla, V;Rubinsztein, David C.;Rudel, Thomas;Rufini, Alessandro;Ryan, Kevin M.;Sarosiek, Kristopher A.;Sawa, Akira;Sayan, Emre;Schroder, Kate;Scorrano, Luca;Sesti, Federico;Shao, Feng;Shi, Yufang;Sica, Giuseppe S.;Silke, John;Simon, Hans-Uwe;Sistigu, Antonella;Stephanou, Anastasis;Stockwell, Brent R.;Strapazzon, Flavie;Strasser, Andreas;Sun, Liming;Sun, Erwei;Sun, Qiang;Szabadkai, Gyorgy;Tait, Stephen W. G.;Tang, Daolin;Tavernarakis, Nektarios;Troy, Carol M.;Turk, Boris;Urbano, Nicoletta;Vandenabeele, Peter;Vanden Berghe, Tom;Vander Heiden, Matthew G.;Vanderluit, Jacqueline L.;Verkhratsky, Alexei;Villunger, Andreas;von Karstedt, Silvia;Voss, Anne K.;Vousden, Karen H.;Vucic, Domagoj;Vuri, Daniela;Wagner, Erwin F.;Walczak, Henning;Wallach, David;Wang, Ruoning;Wang, Ying;Weber, Achim;Wood, Will;Yamazaki, Takahiro;Yang, Huang-Tian;Zakeri, Zahra;Zawacka-Pankau, Joanna E.;Zhang, Lin;Zhang, Haibing;Zhivotovsky, Boris;Zhou, Wenzhao;Piacentini, Mauro;Kroemer, Guido;Galluzzi, Lorenzo
细胞凋亡是调控细胞死亡(RCD)的一种形式，涉及caspase家族的蛋白酶。在哺乳动物系统中通过实验抑制或延迟细胞凋亡的药理学和遗传学策略已经阐明了这一过程不仅对(后)胚胎发育和成人组织动态平衡的关键贡献，而且对多种人类疾病的病因学也有重要贡献。与这一概念一致的是，尽管细胞凋亡的分子机制的缺陷阻碍了器官的发育并促进了肿瘤的发生，但在各种神经、心血管、肾脏、肝脏、感染性、肿瘤和炎症的情况下，不必要的凋亡激活会促进细胞丢失和组织损伤。在这里，细胞死亡命名委员会(NCCD)聚集在一起，批判性地总结了大量的临床前文献，从机械上将核心细胞凋亡装置与疾病背景下的生物动态平衡联系起来。
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
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影响因子：
3.5
作者：
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影响因子：
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