Differential neural processing of value during decision-making in adults with attention-deficit/hyperactivity disorder and healthy controls.
Differential neural processing of value during decision-making in adults with attention-deficit/hyperactivity disorder and healthy controls.
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DOI：
10.1503/jpn.220123
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发表时间：
2023-03
影响因子：
4.3
通讯作者：
Gau, Susan Shur-Fen
中科院分区：
文献类型：
--
作者：
Lee, Chun-Yi;Goh, Joshua Oon Soo;Gau, Susan Shur-Fen
在患有注意力缺陷/多动障碍(ADHD)的成年人中观察到冒险行为。我们试图评估ADHD成人中与冒险决策行为相关的刺激值的神经处理变化，这与学习要求不同。总体而言，32名患有ADHD的成年人和32名没有ADHD的健康对照组在功能磁共振成像(FMRI)实验中进行了抽签选择任务。参与者接受或拒绝带有明确信息的赌注，这些赌注包含不同程度的输赢概率。结果在所有试验中是独立的，绕过了奖励学习。数据分析探索了在选择、决策过程和结果反馈过程中对刺激值的神经行为反应的群体差异。与健康对照组相比，患有ADHD的成年人反应时间较慢，倾向于接受中低概率获胜的更多赌注。与健康对照组相比，ADHD患者有证据表明，与健康对照组相比，ADHD患者的背外侧前额叶皮质(DLPFC)活性降低，感兴趣区的腹内侧前额叶皮质(VMPFC)对概率线性变化的敏感性降低。在健康对照组中，较低的DLPFC反应与较低的VMPFC概率敏感度和较大的风险承担有关，但与ADHD成年人无关。与健康对照组相比，患有ADHD的成年人对壳核和海马体的丢失结果表现出更高的反应。需要对现实生活中的决策行为进行评估，以进一步验证实验结果。我们的发现探索了调节成人ADHD冒险行为的与价值相关的信息的主动性和相位性神经处理。额纹状体环路中行为行为和结果价值的神经计算失调，可能是ADHD成人之间不同于奖励学习差异的决策处理的基础。NCT02642068
Risk-taking behaviours are observed among adults with attention-deficit/hyperactivity disorder (ADHD). We sought to evaluate altered neural processing of stimuli values associated with risk-taking decision behaviour, distinct from learning requirements, among adults with ADHD. Overall, 32 adults with ADHD and 32 healthy controls without ADHD underwent a lottery choice task in a functional magnetic resonance imaging (fMRI) experiment. Participants accepted or rejected stakes with explicit information about variable probabilities of winning or losing points at different magnitudes. Outcomes were independent across trials, circumventing reward learning. Data analysis explored group differences in neurobehavioural responses to stimuli values during choice decision-making processing and outcome feedback. Compared with healthy controls, adults with ADHD had slower response times and tended to accept more stakes with a middle-to-low probability of winning. Adults with ADHD had evidence of lower dorsolateral prefrontal cortex (DLPFC) activity and reduced sensitivity in the ventromedial prefrontal cortex (VMPFC) region of interest in response to linear changes in probability, compared with healthy controls. Lower DLPFC responses were associated with lower VMPFC probability sensitivity and greater risk-taking among healthy controls but not adults with ADHD. Compared with health controls, adults with ADHD showed higher responses to loss outcomes in the putamen and hippocampus. Assessments of real-life decision behaviours are required to further validate the experimental findings. Our findings explore tonic and phasic neural processing of value-related information that modulates risk-taking behaviours among adults with ADHD. Dysregulated neural computation of the values of behavioural actions and outcomes in the frontostriatal circuits may underlie decision processing distinct from reward learning differences among adults with ADHD. NCT02642068
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
15.9
作者：
Hauser TU;Fiore VG;Moutoussis M;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
3.2
作者：
Chen, Yi-Lung;Shen, Lih-Jong;Gau, Susan Shur-Fen
通讯作者：
Gau, Susan Shur-Fen
影响因子：
2.4
作者：
Bangma, Dorien F.;Koerts, Janneke;Tucha, Oliver
通讯作者：
Tucha, Oliver
DOI：
10.1007/s12402-016-0208-3
发表时间：
2017-03
期刊：
Attention deficit and hyperactivity disorders
影响因子：
--
作者：
Fayyad J;Sampson NA;Hwang I;Adamowski T;Aguilar-Gaxiola S;Al-Hamzawi A;Andrade LH;Borges G;de Girolamo G;Florescu S;Gureje O;Haro JM;Hu C;Karam EG;Lee S;Navarro-Mateu F;O'Neill S;Pennell BE;Piazza M;Posada-Villa J;Ten Have M;Torres Y;Xavier M;Zaslavsky AM;Kessler RC;WHO World Mental Health Survey Collaborators
通讯作者：
WHO World Mental Health Survey Collaborators