A specific KRAS codon 13 mutation is an independent predictor for colorectal cancer metachronous distant metastases.
A specific KRAS codon 13 mutation is an independent predictor for colorectal cancer metachronous distant metastases.
复制标题
特定的 KRAS 密码子 13 突变是结直肠癌异时远处转移的独立预测因子。
DOI：
--
复制
发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Xu, Jianmin
中科院分区：
文献类型：
--
作者：
Zhu, Dexiang;Lin, Qi;Zheng, Peng;Xu, Jianmin
结直肠癌的背景，同步转移和同步转移之间存在显着差异。然而，在最近的研究中，同步转移始终集中在一起，忽略了它们的临床和分子
BACKGROUND
In colorectal cancer, there are significant differences between synchronous and metachronous distant metastases. However in recent studies, synchronous and metachronous metastases were always lumped together, neglecting their clinical and molecular differences. The mechanism of the latency of metachronous metastases is still unclear. We conducted this study to reveal the relationship between EGFR pathways and metachronous metastases, and try to find efficient predictors.
METHODS
PCRs and pyrosequencing were used to detect KRAS, BRAF, PIK3CA and PTEN mutations in primary tumor tissues in a total of 281 patients from 2002 to 2008. Patients were identified into three groups: no-metastases group, synchronous-metastases group and metachronous-metastases group. Clinical and survival data were collected from a prospective database.
RESULTS
KRAS codon 13 mutation was an independent predictor only for metachronous distant metastases (OR = 11.857, P < 0.001), but not for synchronous metastases. Male gender (OR = 2.233, P = 0.024), primary tumor located at rectum (OR = 0.404, P = 0.041), and primary pN2 stage (OR = 3.361, P = 0.01) were also independent predictors for metachronous distant metastases. Different SNPs in KRAS worked significantly different in determining synchronous or metachronous metastases. BRAF mutation (Univariate, OR = 11.5, P = 0.039) and > 200 ng/ml preoperative CEA (Univariate, OR = 41, P = 0.011) potentially predicted metastases within 6 months after primary tumor resection. After metachronous metastases, radical resection (HR = 0.280, P = 0.002) was the most important protective factor for long-term survival.
CONCLUSION
There were significant clinical and molecular differences between synchronous and metachronous metastases. As an independent predictor, KRAS codon 13 mutation might be the key to explain the mechanism of colorectal cancer metachronous distant metastases. Together with clinical characteristics, it could aid in the early detection of metachronous metastases.
登录
查看更多内容
影响因子：
6.2
作者：
Mao, Chen;Huang, Ya-Fang;Tang, Jin-Ling
通讯作者：
Tang, Jin-Ling
影响因子：
50.5
作者：
Bokemeyer, C.;Bondarenko, I.;Koralewski, P.
通讯作者：
Koralewski, P.
影响因子：
11.2
作者：
Sílvia Guerrero;I. Casanova;Lourdes Farre;Adela Mazo;G. Capellá;Ramón Mangues
通讯作者：
Sílvia Guerrero;I. Casanova;Lourdes Farre;Adela Mazo;G. Capellá;Ramón Mangues
影响因子：
45.3
作者：
Van Cutsem, Eric;Kohne, Claus-Henning;Ciardiello, Fortunato
通讯作者：
Ciardiello, Fortunato
影响因子：
4
作者：
Roszkowski, Krzysztof;Zurawski, Bogdan;Jozwicki, Wojciech;Basta, Pawel;Lewandowska, Marzena Anna
通讯作者：
Lewandowska, Marzena Anna