The Diamond STING server.

The Diamond STING server.
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DOI:
10.1093/nar/gki397
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发表时间:
2005-07-01
影响因子:
14.9
通讯作者:
Mancini, AL
Mancini, AL
中科院分区:
生物学2区
文献类型:
--
作者:
Neshich, G;Borro, LC;Higa, RH;Kuser, PR;Yamagishi, MEB;Franco, EH;Krauchenco, JN;Fileto, R;Ribeiro, AA;Bezerra, GBP;Velludo, TM;Jimenez, TS;Furukawa, N;Teshima, H;Kitajima, K;Bava, A;Sarai, A;Togawa, RC;Mancini, AL

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钻石STING是STING程序套件的新版本,用于全面分析蛋白质序列、结构、功能和稳定性之间的关系。我们为STING数据库提供了更多的结构参数,并改进/扩展了接口以增强数据处理,从而增加了许多新功能。STIN组件之间的集成度也得到了提高。一项新的关键功能是STIN服务器能够处理包含蛋白质结构的本地文件(无论是建模的还是尚未存入蛋白质数据库的),以便主要的STIN组件使用它们:Java Protein档案(JPD)和STIN报告。这里描述了新的STING版本的当前功能和几个与生物相关的应用。我们已经提供了一个例子,其中钻石刺通过选择一组相应参数的数值/范围来过滤掉除那些残基之外的所有残基,从而识别活性部位氨基酸和折叠必需氨基酸(两者都是以前通过实验确定的)。这是朝着更有趣的努力--预测这种残基--迈出的根本一步。钻石刺可以在和免费获得。
Diamond STING is a new version of the STING suite of programs for a comprehensive analysis of a relationship between protein sequence, structure, function and stability. We have added a number of new functionalities by both providing more structure parameters to the STING Database and by improving/expanding the interface for enhanced data handling. The integration among the STING components has also been improved. A new key feature is the ability of the STING server to handle local files containing protein structures (either modeled or not yet deposited to the Protein Data Bank) so that they can be used by the principal STING components: JavaProtein Dossier (JPD) and STING Report. The current capabilities of the new STING version and a couple of biologically relevant applications are described here. We have provided an example where Diamond STING identifies the active site amino acids and folding essential amino acids (both previously determined by experiments) by filtering out all but those residues by selecting the numerical values/ranges for a set of corresponding parameters. This is the fundamental step toward a more interesting endeavor—the prediction of such residues. Diamond STING is freely accessible at and .
DOI: 10.1093/nar/gkg578
发表时间: 2003-07-01
影响因子: 14.9
作者:
Neshich, G;Togawa, RC;Higa, RH
通讯作者: Higa, RH
DOI: 10.1093/bioinformatics/bth203
发表时间: 2004-09-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者:
Mancini, AL;Higa, RH;Neshich, G
通讯作者: Neshich, G
DOI: 10.1093/nar/25.1.226
发表时间: 1997-01-01
影响因子: 14.9
作者:
Schneider, R;deDaruvar, A;Sander, C
通讯作者: Sander, C
DOI: 10.1002/prot.340090107
发表时间: 1991-01-01
期刊: PROTEINS-STRUCTURE FUNCTION AND GENETICS
影响因子: --
作者:
SANDER, C;SCHNEIDER, R
通讯作者: SCHNEIDER, R
DOI: 10.1093/nar/24.1.201
发表时间: 1996-01-01
影响因子: 14.9
作者:
Schneider, R;Sander, C
通讯作者: Sander, C