CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer.
CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer.
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DOI：
10.1038/sj.bjc.6604307
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发表时间：
2008-04-22
影响因子：
8.8
通讯作者：
Takao, S.
中科院分区：
文献类型：
--
作者：
Maeda, S.;Shinchi, H.;Kurahara, H.;Mataki, Y.;Maemura, K.;Sato, M.;Natsugoe, S.;Aikou, T.;Takao, S.
虽然CD133已被证明是多种肿瘤中肿瘤干细胞的标志物，但其在胰腺癌中的表达尚未见临床报道。本研究探讨CD133在胰腺癌中的表达及其与临床病理因素的关系。应用免疫组织化学方法检测80例胰头癌手术切除标本中CD133、血管内皮生长因子C、CXCR4、CD34、Ki-67和细胞角蛋白(CK)的表达。60%(48/80)的标本CD133阳性，每个标本表达CD133的细胞不到15%。CD133阳性细胞位于腺癌腺体结构的周边部位，CK阴性。CD133的表达与组织学类型、淋巴侵犯、淋巴结转移等临床病理因素显著相关(P分别为0.0215、0.0023和0.0024)。血管内皮生长因子-C的表达与CD133的表达也显著相关(P=0.0002)。CD133表达阳性患者的5年生存率显著低于CD133阴性患者(P=0.0002)，多因素分析显示CD133表达是独立的预后因素(P=0.0103)。提示CD133在胰腺癌中的表达与胰腺癌的淋巴转移、血管内皮生长因子C的表达及预后密切相关。
Although CD133 has been shown to be a marker for cancer stem cells in various tumours, its expression in pancreatic cancer has not yet been clinically reported. In this study, we investigated the relationship between CD133 expression and clinicopathological factors in pancreatic cancer. Pancreatic head carcinoma specimens from 80 patients who underwent surgical resection were immunohistochemically assessed for CD133, vascular endothelial growth factor (VEGF)-C, CXCR4, CD34, Ki-67, and cytokeratin (CK) expressions. Sixty percentage (48/80) of specimens were CD133-positive, with less than 15% cells per specimen expressing the marker. CD133-positive cells were found at the peripheral site of adenocarcinoma glandular structures and were negative for CK. There was a significant correlation between CD133 expression and clinicopathological factors, including histological type, lymphatic invasion, and lymph node metastasis (P=0.0215, 0.0023, and 0.0024, respectively). Vascular endothelial growth factor-C expression was also significantly correlated with CD133 expression (P=0.0002). Consequently, the 5-year survival rate of CD133-positive patients was significantly lower than that of CD133-negative patients (P=0.0002) and multivariate analysis revealed that CD133 expression was an independent prognostic factor (P=0.0103). These results suggest that CD133 expression in pancreatic cancer was significantly associated with lymphatic metastasis, VEGF-C expression, and prognosis.
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影响因子：
8.8
作者：
Maeda, S.;Shinchi, H.;Kurahara, H.;Mataki, Y.;Noma, H.;Maemura, K.;Aridome, K.;Yokomine, T.;Natsugoe, S.;Aikou, T.;Takao, S.
通讯作者：
Takao, S.
影响因子：
11.5
作者：
Mehra, Niven;Penning, Maarten;Voest, Emile E.
通讯作者：
Voest, Emile E.
影响因子：
11.2
作者：
Miki, Jun;Furusato, Bungo;Rhim, Johng S.
通讯作者：
Rhim, Johng S.
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
11.2
作者：
Li, Chenwei;Heidt, David G.;Simeone, Diane M.
通讯作者：
Simeone, Diane M.