Clinical significance of midkine expression in pancreatic head carcinoma.
Clinical significance of midkine expression in pancreatic head carcinoma.
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DOI：
10.1038/sj.bjc.6603879
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发表时间：
2007-08-06
影响因子：
8.8
通讯作者：
Takao, S.
中科院分区：
文献类型：
--
作者：
Maeda, S.;Shinchi, H.;Kurahara, H.;Mataki, Y.;Noma, H.;Maemura, K.;Aridome, K.;Yokomine, T.;Natsugoe, S.;Aikou, T.;Takao, S.
中期因子（MK）是一种肝素结合生长因子，是视黄酸反应基因的产物。中期因子在许多肿瘤中过度表达，并被认为在肿瘤发生中起重要作用。然而，没有研究集中在MK在胰腺癌中的作用。本研究旨在探讨MK在胰头癌组织中的表达及其临床意义，包括MK表达与临床病理因素如预后的关系。对75例接受手术切除的胰头癌患者的标本进行了MK和CD 34的免疫组织化学表达评估。中期因子在53.3%的患者中表达。中期因子表达与静脉浸润、微血管密度和肝转移显著相关（P分别为0.0063、0.0025和0.0153）。MK阳性患者的5年生存率显著低于MK阴性患者（P=0.0073）。多因素分析显示MK表达是独立的预后因素（P=0.0033）。这是第一次报告MK表达和胰头癌之间的关联。中期因子可能在胰头癌的发生发展中起重要作用，检测MK的表达有助于预测胰头癌的恶性性质。
Midkine (MK) is a heparin-binding growth factor and a product of a retinoic acid-responsive gene. Midkine is overexpressed in many carcinomas and thought to play an important role in carcinogenesis. However, no studies have been focussed on the role of MK in pancreatic carcinoma. This study sought to evaluate the clinical significance of MK expression in pancreatic head carcinoma, including the relationship between immunohistochemical expression and clinicopathologic factors such as prognosis. Immunohistochemical expression of MK and CD34 was evaluated in pancreatic head carcinoma specimens from 75 patients who underwent surgical resection. Midkine was expressed in 53.3% of patients. Midkine expression was significantly correlated with venous invasion, microvessel density, and liver metastasis (P=0.0063, 0.0025, and 0.0153, respectively). The 5-year survival rate was significantly lower for patients positive for MK vs patients negative for MK (P=0.0073). Multivariate analysis revealed that MK expression was an independent prognostic factor (P=0.0033). This is the first report of an association between MK expression and pancreatic head carcinoma. Midkine may play an important role in the progression of pancreatic head carcinoma, and evaluation of MK expression is useful for predicting malignant properties of pancreatic head carcinoma.
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