Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis.

Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis.
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DOI:
10.3390/brainsci11020244
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发表时间:
2021-02-15
期刊:
影响因子:
3.3
通讯作者:
Paraskevas GP
Paraskevas GP
中科院分区:
医学4区
文献类型:
--
作者:
Ntymenou S;Tsantzali I;Kalamatianos T;Voumvourakis KI;Kapaki E;Tsivgoulis G;Stranjalis G;Paraskevas GP

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脑脊液 (CSF) 中的生物标志物可用于额颞叶痴呆 (FTD) 和阿尔茨海默氏痴呆 (AD) 的鉴别诊断,但需要腰椎穿刺,这是一种中度侵入性操作,可能会导致患者焦虑。逐渐地,血液生物标志物的测量引起了人们的极大兴趣。为了测量生物标志物,测试血液而不是脑脊液具有许多优点,因为它不需要腰椎穿刺,它广泛可用,并且可以重复,可以预测病程。在这项研究中,对现有文献进行了系统回顾,并对研究最多的生物标志物 p-tau 和颗粒体蛋白前体进行了荟萃分析。目标是突出有关在临床实践中使用血浆生物标志物的证据。
Biomarkers in cerebrospinal fluid (CSF) are useful in the differential diagnosis between frontotemporal dementia (FTD) and Alzheimer’s dementia (AD), but require lumbar puncture, which is a moderately invasive procedure that can cause anxiety to patients. Gradually, the measurement of blood biomarkers has been attracting great interest. Testing blood instead of CSF, in order to measure biomarkers, offers numerous advantages because it negates the need for lumbar puncture, it is widely available, and can be repeated, allowing the prediction of disease course. In this study, a systematic review of the existing literature was conducted, as well as meta-analysis with greater emphasis on the most studied biomarkers, p-tau and progranulin. The goal was to give prominence to evidence regarding the use of plasma biomarkers in clinical practice.
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