Lipid metabolism and Drosophila sperm development

Lipid metabolism and Drosophila sperm development
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脂质代谢与果蝇精子发育

DOI:
10.1007/s11427-012-4274-2
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发表时间:
2012-01
期刊:
Science China Life Sciences
影响因子:
--
通讯作者:
Huang Xun
Huang Xun
中科院分区:
其他
文献类型:
--
作者:
Wang Chao;Huang Xun

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脂质是细胞膜的基本结构成分和重要的信号载体。各种脂质(磷脂、鞘脂、胆固醇)的主要酶代谢已得到充分研究。在大多数情况下,脂质代谢的发育功能仍然是难以捉摸的。在新技术和模式生物的帮助下,脂质代谢在发育中的重要作用才开始显现。果蝇精子发生是研究发育过程中胞质分裂和膜重构的理想系统。磷脂酰肌醇(PI)脂质、脂肪酸和胆固醇等多种脂类的代谢调节因子在果蝇精子发生的各个阶段起着重要作用。在这篇简短的综述中,我们总结了最近的研究结果,支持脂质代谢和果蝇精子发育之间的紧密联系。
Lipids are essential membrane structural components and important signal carriers. The major enzymatic metabolisms of various lipids (phospholipid, sphingolipid, cholesterol) are well studied. The developmental function of lipid metabolism has remained, for the most part, elusive. With the help of new techniques and model organisms, the important roles of lipid metabolism in development just start to emerge. Drosophila spermatogenesis is an ideal system for in vivo studies of cytokinesis and membrane remodeling during development. The metabolic regulators of many lipids, including phosphatidylinositol (PI) lipids, fatty acids and cholesterol, are reported to play critical roles in various steps during Drosophila spermatogenesis. In this mini-review, we summarized recent findings supporting a tight link between lipids metabolism and Drosophila sperm development.
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影响因子: 4.6
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