CD84 is a survival receptor for CLL cells.
CD84 is a survival receptor for CLL cells.
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慢性淋巴细胞白血病（CLL）是一种成熟淋巴细胞的恶性肿瘤，表现为转化细胞的进行性积累，主要是由于细胞凋亡减少。CD84属于免疫受体信号转导淋巴细胞激活分子（Signaling Lymphocyte Activating Molecule， SLAM）家族，在正常B细胞和CLL淋巴细胞中的功能尚不清楚。我们发现CD84在CLL细胞中过表达。细胞表面CD84的激活启动信号级联，从而提高细胞存活率。免疫中和或阻断CD84均可诱导细胞在体内和体外死亡。因此，早期CD84的过表达可能对CLL的生存至关重要。这些发现提示了基于阻断CD84依赖性生存途径的新治疗策略。
Chronic lymphocytic leukemia (CLL) is a malignancy of mature lymphocytes that is manifest by the progressive accumulation of transformed cells, mostly due to their decreased apoptosis. CD84 belongs to the Signaling Lymphocyte Activating Molecule (SLAM) family of immunoreceptors and has an as yet unknown function in normal B cells and CLL lymphocytes. We show that CD84 is over-expressed in CLL cells. Activation of cell surface CD84 initiates a signaling cascade, which enhances cell survival. Both immunoneutralization or blockade of CD84 induce cell death in vitro and in vivo. Thus, overexpression of CD84 from an early stage may be critical for the survival of CLL. These findings suggest novel therapeutic strategies based on the blockade of a CD84 dependent survival pathway.
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DOI：
10.1073/pnas.0701553104
发表时间：
2007-08-14
影响因子：
11.1
作者：
Binsky, Inbal;Haran, Michal;Shachar, Idit
通讯作者：
Shachar, Idit
影响因子：
20.3
作者：
Flaishon, L;Becker-Herman, S;Shachar, I
通讯作者：
Shachar, I
影响因子：
11.4
作者：
Haran, M;Chebatco, S;Shachar, I
通讯作者：
Shachar, I
影响因子：
3.2
作者：
Calpe, S;Erdös, E;Lanyi, A
通讯作者：
Lanyi, A
影响因子：
11.2
作者：
Hartmann, Tanja Nicole;Grabovsky, Valentin;Alon, Ronen
通讯作者：
Alon, Ronen