Quantitative modeling of Cerenkov light production efficiency from medical radionuclides.
Quantitative modeling of Cerenkov light production efficiency from medical radionuclides.
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DOI：
10.1371/journal.pone.0031402
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Hielscher AH
中科院分区：
文献类型：
--
作者：
Beattie BJ;Thorek DL;Schmidtlein CR;Pentlow KS;Humm JL;Hielscher AH
近年来，人们对切伦科夫辐射(CR)用于生物应用的兴趣与日俱增。了解各种放射性核素产生的CR的生产效率和其他特性将有助于评估拟议应用的可行性，并指导放射性核素的选择。为了产生这些信息，我们建立了基于Frank-Tamm方程的CR生产效率模型和基于光子和β粒子输运的蒙特卡罗模拟的CR分布模型。所有模型都通过使用多种放射性核素的直接测量进行了验证，然后应用于生物医学应用中常用的一些放射性核素。我们发现，已报道在水中产生CR的两种放射性核素Ac-225和In-111实际上并不直接产生CR。我们还提出了一种利用这些信息来校准高灵敏度发光成像系统的简单方法，并展示了证据表明，这种校准可能比目前常规使用的方法更准确。
There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use.
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影响因子：
3.7
作者：
Liu H;Ren G;Miao Z;Zhang X;Tang X;Han P;Gambhir SS;Cheng Z
通讯作者：
Cheng Z
影响因子：
3.5
作者：
Dehghani, H;Brooksby, B;Paulsen, KD
通讯作者：
Paulsen, KD
影响因子：
--
作者：
BETHE, HA
通讯作者：
BETHE, HA
影响因子：
3.7
作者：
Dothager RS;Goiffon RJ;Jackson E;Harpstrite S;Piwnica-Worms D
通讯作者：
Piwnica-Worms D
影响因子：
13.3
作者：
Liu, Hongguang;Zhang, Xiaofen;Cheng, Zhen
通讯作者：
Cheng, Zhen