Genetic factors modulate the impact of pubertal androgen excess on insulin sensitivity and fertility.
Genetic factors modulate the impact of pubertal androgen excess on insulin sensitivity and fertility.
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DOI：
10.1371/journal.pone.0079849
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hill JW
中科院分区：
文献类型：
--
作者：
Dowling AR;Nedorezov LB;Qiu X;Marino JS;Hill JW
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive age women. The syndrome is caused by a combination of environmental influences and genetic predisposition. Despite extensive efforts, the heritable factors contributing to PCOS development are not fully understood. The objective of this study was to test the hypothesis that genetic background contributes to the development of a PCOS-like reproductive and metabolic phenotype in mice exposed to excess DHEA during the pubertal transition. We tested whether the PCOS phenotype would be more pronounced on the diabetes-prone C57BL/6 background than the previously used strain, BALB/cByJ. In addition, we examined strain-dependent upregulation of the expression of ovarian and extra-ovarian candidate genes implicated in human PCOS, genes containing known strain variants, and genes involved with steroidogenesis or insulin sensitivity. These studies show that there are significant strain-related differences in metabolic response to excess androgen exposure during puberty. Additionally, our results suggest the C57BL/6J strain provides a more robust and uniform experimental platform for PCOS research than the BALB/cByJ strain.
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DOI：
10.1111/j.1471-0528.2006.01008.x
发表时间：
2006-10-01
影响因子：
5.8
作者：
Broekmans, F. J.;Knauff, E. A. H.;Fauser, B. C. J. M.
通讯作者：
Fauser, B. C. J. M.
DOI：
10.1152/ajpendo.00332.2001
发表时间：
2002-04-01
影响因子：
5.1
作者：
Burcelin, M;Crivelli, V;Thorens, B
通讯作者：
Thorens, B
影响因子：
3.2
作者：
CLAYTON, RN;OGDEN, V;MEADE, TW
通讯作者：
MEADE, TW
影响因子：
5.8
作者：
Jakimiuk, AJ;Weitsman, SR;Magoffin, DA
通讯作者：
Magoffin, DA
影响因子：
5.8
作者：
Ewens, Kathryn G.;Stewart, Douglas R.;Spielman, Richard S.
通讯作者：
Spielman, Richard S.