Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.
Impact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease.
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DOI：
10.1186/s12890-017-0544-x
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发表时间：
2017-12-13
影响因子：
3.1
通讯作者：
Hasegawa N
中科院分区：
文献类型：
--
作者：
Kamata H;Asakura T;Suzuki S;Namkoong H;Yagi K;Funatsu Y;Okamori S;Uno S;Uwamino Y;Fujiwara H;Nishimura T;Ishii M;Betsuyaku T;Hasegawa N
在支气管扩张症患者中，慢性铜绿假单胞菌（PA）感染与健康相关生活质量（HRQL）较差相关，但在此背景下对鸟分枝杆菌复合型肺病（MACLD）患者知之甚少。本研究旨在评估HRQL并研究慢性PA感染对MACLD患者的影响。这项横断面研究是使用前瞻性队列研究登记研究（包括MACLD患者）进行的。采用36项健康调查简表（SF-36）和圣乔治呼吸问卷（SGRQ）评估临床结局。临床变量包括治疗和痰培养状态、肺功能检查、空洞性病变和高分辨率计算机断层扫描的改良雷夫评分。该研究包括244名MACLD患者（中位年龄68岁; 196名女性），其中19名患有慢性PA感染。慢性感染组的改良雷夫评分高于非慢性感染组（P = 0.028）。关于SF-36评分，慢性感染患者的身体功能子量表评分显著较低（P = 0.029）。此外，慢性感染患者的SGRQ症状、影响和总分显著较高。在协方差比较分析中，慢性感染患者的SGRQ症状和影响评分显著较高（分别为P = 0.043和0.021）。慢性PA感染的MACLD患者表现出显著更高的SGRQ评分，表明HRQL受损。慢性PA感染与支气管扩张的严重程度显著相关。
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact of chronic PA infection in MACLD patients. This cross-sectional study was conducted using the Registry of Prospective Cohort Study including MACLD patients. The 36-item Short-Form health survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ) were administered to assess clinical outcomes. Clinical variables included treatment and sputum culture status, pulmonary function tests, cavitary lesions, and modified Reiff scores on high-resolution computed tomography. The study included 244 MACLD patients (median age, 68 years; 196 women), 19 of whom had chronic PA infection. Modified Reiff score was higher in patients with chronic infection than in those without (P = 0.028). Regarding SF-36 scores, physical functioning subscale scores were significantly lower in patients with chronic infection (P = 0.029). Additionally, SGRQ symptoms, impact, and total scores were significantly higher in patients with chronic infection. During analysis of covariance comparisons, SGRQ symptoms and impact scores were significantly higher for patients with chronic infection (P = 0.043 and 0.021, respectively). MACLD patients with chronic PA infection exhibited significantly higher SGRQ scores, indicating impaired HRQL. Chronic PA infection was significantly associated with the severity of bronchiectasis.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
3.7
作者：
Chen AC;Martin ML;Lourie R;Rogers GB;Burr LD;Hasnain SZ;Bowler SD;McGuckin MA;Serisier DJ
通讯作者：
Serisier DJ
DOI：
10.1164/rccm.201309-1575oc
发表时间：
2014-03-01
影响因子：
24.7
作者：
Chalmers, James D.;Goeminne, Pieter;Hill, Adam T.
通讯作者：
Hill, Adam T.
影响因子：
5.6
作者：
Faverio, Paola;Stainer, Anna;Aliberti, Stefano
通讯作者：
Aliberti, Stefano
影响因子：
4.1
作者：
Fujita K;Ito Y;Hirai T;Kubo T;Togashi K;Ichiyama S;Mishima M
通讯作者：
Mishima M